Clinical validation of the 2017 international consensus guidelines on intraductal papillary mucinous neoplasm of the pancreas

Annals of Surgical Treatment and Research
Jae Seung KangJin-Young Jang

Abstract

The 2017 international consensus guidelines (ICG) for intraductal papillary mucinous neoplasm (IPMN) of the pancreas were recently released. Important changes included the addition of worrisome features such as elevated serum CA 19-9 and rapid cyst growth (>5 mm over 2 years). We aimed to clinically validate the 2017 ICG and compare the diagnostic performance between the 2017 and 2012 ICG. This was a retrospective cohort study. During January 2000-January 2017, patients who underwent complete surgical resection and had pathologic confirmation of branch-duct or mixed-type IPMN were included. To evaluate diagnostic performance, the areas under the receiver operating curves (AUCs) were evaluated. A total of 448 patients were included. The presence of mural nodule (hazard ratio [HR], 9.12; 95% confidence interval [CI], 4.60-18.09; P = 0.001), main pancreatic duct dilatation (>5 mm) (HR, 5.32; 95% CI, 2.67-10.60; P = 0.001), thickened cystic wall (HR, 3.40; 95% CI, 1.51-7.63; P = 0.003), and elevated CA 19-9 level (>37 unit/mL) (HR, 5.25; 95% CI, 2.05-13.42; P = 0.001) were significantly associated with malignant IPMN. Malignant lesions showed a cyst growth rate >5 mm over 2 years more frequently than benign lesions (60.9% vs. 29.7%...Continue Reading

References

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Jul 25, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaChristopher L Wolfgang

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Citations

Apr 18, 2020·Journal of Magnetic Resonance Imaging : JMRI·Kate A HarringtonRichard K G Do
Jul 21, 2020·World Journal of Gastroenterology : WJG·Andrew EitermanSomashekar G Krishna
Feb 14, 2020·International Journal of Molecular Sciences·Scarlett HaoAlexander A Parikh
Apr 2, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Bita GeramizadehZahra Maleki

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BETA
surgical resection

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