Abstract
Diagnosis of invasive candidiasis (IC) is still challenging due to absence of specific clinical signs and symptoms. In this study we investigate the clinical value of (1,3)-β-D-glucan (BDG), mannan (MN), antimannan immunoglobulin G (AM-IgG), and antimannan immunoglobulin M (AM-IgM) assay in diagnosis of IC. During 2016 to 2018 serum samples from 71 patients with IC and 185 patients without IC were collected. Serum samples from 41 patients with bacteremia were also enrolled as additional control. Significant differences in mean serum biomarkers levels between IC and control group were observed. At low cutoff threshold the sensitivity and specificity of BDG (70 pg/ml), MN (50 pg/ml), AM-IgG (80 AU/ml), and AM-IgM (80 AU/ml) assay were 64.8% and 90.8%, 64.8 and 89.2%,74.6% and 87.0%, 57.7% and 60.0%, respectively. Combined use of BDG/MN, BDG/AM-IgG and MN/AM-IgG improved the sensitivity and specificity to 85.9% and 81.1%, 85.9% and 80.0%, 81.7% and 81.6%, respectively. The combination of BDG/MN, BDG/AM-IgG, or MN/AM-IgG may provide an encouraging approach for diagnosis of IC.
References
Oct 9, 2003·Journal of Clinical Microbiology·Boualem SendidDaniel Poulain
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Matthew MorrellMarin H Kollef
Jun 8, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin W GareyDavid T Bearden
Sep 6, 2007·BMC Infectious Diseases·Fasahat F AlamZia U Khan
Apr 17, 2009·Journal of Medical Microbiology·Michael EllisUlla Hedstrom
Dec 15, 2010·Critical Care : the Official Journal of the Critical Care Forum·Malgorzata MikulskaUNKNOWN Third European Conference on Infections in Leukemia Group
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Drosos E KarageorgopoulosMatthew E Falagas
Apr 12, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O AlbertI Villena
Nov 15, 2011·Journal of Clinical Microbiology·Akira OnishiShunichi Kumagai
Jul 4, 2012·Intensive Care Medicine·Cristóbal LeónOsvaldo Fariñas
Jul 14, 2012·Diagnostic Microbiology and Infectious Disease·Nkechi AzieDavid Horn
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
Jan 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Feb 1, 2013·Journal of Clinical Microbiology·Jürgen HeldGeorg Häcker
Jun 21, 2013·American Journal of Respiratory and Critical Care Medicine·Frederic TissotUNKNOWN Fungal Infection Network of Switzerland (FUNGINOS)
Apr 18, 2014·Journal of Clinical Microbiology·Annie SulahianPatricia Ribaud
Jun 18, 2014·Medical Mycology·Bernabé F F ChumpitaziClaudine Pinel
Apr 23, 2015·The Journal of Antimicrobial Chemotherapy·M Carmen Martínez-JiménezEmilio Bouza
Feb 27, 2016·Mycoses·Wiebke DuettmannMartin Hoenigl
May 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·Cristóbal LeónUNKNOWN Cava Trem Study Group
Mar 25, 2017·Medical Mycology·P Lewis WhiteRosemary A Barnes