Clinical value of circulating ESR1 mutations for patients with metastatic breast cancer: a meta-analysis

Cancer Management and Research
Kai ZhangShusen Wang

Abstract

The clinical implication of plasma ESR1 mutations in the estrogen receptor (ER)-positive metastatic breast cancer (MBC) patients who had progressed after prior aromatase inhibitor (AI)-based therapy remains controversial. We conducted the first meta-analysis to investigate the prognostic significance and predictive role of plasma ESR1 mutations in MBC patients with prior exposure to AI therapy. We searched PubMed, Embase, and Cochrane Library databases for eligible studies. Meta-analysis was conducted to calculate combined hazard ratios (HRs) with 95% CIs for progression-free survival (PFS) and overall survival (OS). Subgroup and sensitivity analyses were also performed. This study enrolled a total of 1,530 patients with ER-positive MBC cases from six articles, including 429 ESR1 mutation carriers (28.04%). Meta-analysis demonstrated that plasma ESR1 mutation carriers had significantly worse PFS (HR: 1.40, 95% CI: 1.17-1.66; P<0.0001) and OS (HR: 1.65, 95% CI: 1.36-2.01; P<0.0001) compared to wild-type ESR1. Subgroup analysis showed that plasma ESR1 mutations were associated with shorter PFS after AI-based treatment, but were not significantly predictive of outcome on fulvestrant-containing therapy (HR: 1.26, 95% CI: 0.98-1.62;...Continue Reading

Citations

Nov 2, 2018·Breast Cancer Research and Treatment·Małgorzata SzostakowskaAnna Fabisiewicz
Jun 13, 2019·Expert Review of Molecular Diagnostics·Marcela CarausuLuc Cabel
Nov 2, 2019·Acta Oncologica·Lubaid SalehIngunn Holen
Sep 25, 2019·Nature Reviews. Disease Primers·Nadia HarbeckFatima Cardoso
May 6, 2020·Cancer Metastasis Reviews·Pieter A BoonstraAnna K L Reyners
May 13, 2019·Biochemical Genetics·Yanyan LiuMaoming Xiong
Dec 2, 2020·British Journal of Cancer·Derek DustinSuzanne A W Fuqua
Mar 18, 2021·Future Oncology·Charlene KayArran K Turnbull

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