PMID: 9426091Jan 13, 1998Paper

Clinical value of CYFRA 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer

The European Respiratory Journal
J BatesJ J Gilmartin

Abstract

In this study we looked at what useful information cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 (CYFRA 21.1), carcinoembryonic antigen (CEA), neurone-specific enolase (NSE), tissue polypeptide specific antigen (TPS), and tissue polypeptide antigen (TPA) gave when measured prospectively. All patients who were suspected of having lung cancer and who underwent diagnostic bronchoscopy in this hospital between July 1994 and May 1995 were included in the study. Of 184 patients, 87 were subsequently found to have intrathoracic malignancy, 93 were found to have benign lung disease and four were lost to follow-up. CYFRA 21.1 was the most efficient marker in differentiating benign from malignant disease, with a sensitivity of 54% and a positive predictive value of 96%. Thirty seven patients who had a negative bronchoscopy subsequently turned out to have malignant disease. Either CYFRA 21.1 or CEA was elevated in 26 (70%) of such patients. Multivariate analysis showed that only CYFRA 21.1 and CEA contributed significantly to the discriminatory power of the data. We conclude that measurement of cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 and carcinoembryonic antigen at the time of bronchoscopy signi...Continue Reading

Citations

Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M CioffiA M Molinari
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G Buccheri, D Ferrigno
Feb 26, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ioannis KalomenidisSpyros Papiris
Jan 4, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·R JankowskaW A Gorczyca
Mar 21, 2002·Expert Review of Molecular Diagnostics·G Buccheri, D Ferrigno
Feb 5, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jeffrey A BorgiaMichael J Liptay
Apr 5, 2013·Asia-Pacific Journal of Clinical Oncology·Jian LiLi-Rong Zhu
Apr 17, 1999·Clinics in Chest Medicine·R P Baughman, E M Pina
Apr 3, 2003·Nature Reviews. Cancer·Ruth EtzioniLeland Hartwell
Sep 23, 2010·British Journal of Cancer·E C FarlowJ A Borgia
Dec 18, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Gregory J TsongalisChristopher I Amos
Jan 1, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·G HillasP Bakakos

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