Clinical value of FDG-PET/CT in bacteremia of unknown origin with catalase-negative gram-positive cocci or Staphylococcus aureus

European Journal of Nuclear Medicine and Molecular Imaging
Mette Bordinggaard BrøndserudSøren Hess

Abstract

Bacteremia is associated with high mortality, especially when the site of infection is unknown. While conventional imaging usually focus on specific body parts, FDG-PET/CT visualizes hypermetabolic foci throughout the body. To investigate the ability of FDG/PET-CT to detect the site of infection and its clinical impact in bacteremia of unknown origin with catalase-negative Gram-positive cocci (excluding pneumococci and enterococci) or Staphylococcus aureus (BUOCSA). We retrospectively identified 157 patients with 165 episodes of BUOCSA, who subsequently underwent FDG-PET/CT. Data were collected from medical records. Decision regarding important sites of infection in patients with bacteremia was based on the entire patient course and served as reference diagnosis for comparison with FDG-PET/CT findings. FDG-PET/CT was considered to have high clinical impact if it correctly revealed site(s) of infection in areas not assessed by other imaging modalities or if other imaging modalities were negative/equivocal in these areas, or if it established a new clinically relevant diagnosis, and/or led to change in antimicrobial treatment. FDG-PET/CT detected sites of infection in 56.4% of cases and had high clinical impact in 47.3%. It was t...Continue Reading

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Citations

Sep 5, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Abass AlaviPoul Flemming Høilund-Carlsen
Jul 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nesrin Ghanem-ZoubiMical Paul
Oct 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Feb 23, 2020·Annals of Nuclear Medicine·Yaming LiXiao-Feng Li
Mar 7, 2021·Journal of Personalized Medicine·Jordy P PijlAndor W J M Glaudemans
Apr 9, 2021·Critical Care : the Official Journal of the Critical Care Forum·Jordy P PijlJanesh Pillay

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