Clinical Value of Tumor Markers for Determining Cause of Pleural Effusion

Chinese Medical Journal
Yan GuHuan-Zhong Shi

Abstract

It is often challenging to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE); thoracoscopy is among the techniques with the highest diagnostic ability in this regard. However, such invasive examinations cannot be performed on the elderly, or on those in poor physical condition. The aim of this study was to explore the differential diagnostic value of carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and squamous cell carcinoma (SCC) associated antigen in patients with TPE and MPE. Using electrochemiluminescence, we measured the concentration of tumor markers (TMs) in the pleural effusion and serum of patients with TPE (n = 35) and MPE (n = 95). We used receiver operating characteristic (ROC) curve analysis to evaluate the TMs and differentiate between TPE and MPE. The cut-off values for each TM in serum were: CA125, 151.55 U/ml; CA199, 9.88 U/ml; CEA, 3.50 ng/ml; NSE, 13.27 ng/ml; and SCC, 0.85 ng/ml. Those in pleural fluid were: CA125, 644.30 U/ml; CA199, 12.08 U/ml; CEA, 3.35 ng/ml; NSE, 9.71 ng/ml; and SCC, 1.35 ng/ml. The cut-off values for the ratio of pleural fluid concentration to serum concentration (P/S r...Continue Reading

References

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Citations

Feb 24, 2018·Biochemia Medica·Darian VolarićLjiljana Bulat-Kardum
Sep 12, 2018·Chinese Medical Journal·Li Zhou, Feng-Lin Peng
Jun 18, 2019·Therapeutic Advances in Medical Oncology·Klaus HacknerSabin Handzhiev
Dec 17, 2020·Risk Management and Healthcare Policy·Ling GongXiaoping Tang

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Methods Mentioned

BETA
X-ray

Software Mentioned

SPSS

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