Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: a retrospective cohort study.

Inflammatory Bowel Diseases
Jill C MooreStephen L Guthery

Abstract

Clinical variables may identify a subset of patients with pediatric-onset ulcerative colitis (UC) (≤18 years at diagnosis) at risk for adverse outcomes. We postulated that routinely measured clinical variables measured at diagnosis would predict colectomy in patients with pediatric-onset UC. We conducted a chart review of patients with pediatric-onset UC at a single center over a 10-year period. We compared patients with and without colectomy across several variables, used proportional hazards regression to adjust for potential confounders, and assessed the ability of a UC risk score to predict colectomy. Among 470 patients with inflammatory bowel disease ICD9-coded encounters, 155 patients had UC and 135 were eligible for analysis. The 1- and 3-year colectomy rates were 16.7% (95% confidence interval [CI]: 11.0%-24.8%) and 35.6% (26.7%-45.4%). White blood cell (WBC) count and hematocrit measured at diagnosis were associated with colectomy at 3 years, even after correcting for potential confounding variables. A UC Risk Score derived from the WBC count and hematocrit was strongly associated with colectomy risk, with a high negative predictive value (NPV) for colectomy at 1 and 3 years (NPV = 0.95 and 0.89, respectively), but low...Continue Reading

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Apr 11, 2013·Pediatric Surgery International·Jarod P McAteerAdam B Goldin
Nov 10, 2012·World Journal of Gastroenterology : WJG·Andrew S DayDaniel A Lemberg
Apr 16, 2013·Journal of Crohn's & Colitis·Marina AloiSalvatore Cucchiara
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Dec 6, 2011·Inflammatory Bowel Diseases·Nicolas WillietLaurent Peyrin-Biroulet
Aug 8, 2012·Nature Reviews. Gastroenterology & Hepatology·Salvatore Cucchiara, Laura Stronati
Jun 1, 2018·Journal of Pediatric Gastroenterology and Nutrition·Dan TurnerRichard K Russell
Aug 20, 2020·Inflammatory Bowel Diseases·Yael Haberman
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Jun 11, 2020·Journal of Pediatric Gastroenterology and Nutrition·David R MackUNKNOWN PROTECT STUDY GROUP
Jun 12, 2012·Journal of Pediatric Gastroenterology and Nutrition·Lorraine I Kelley-QuonStephen B Shew

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