PMID: 8946970Dec 1, 1996Paper

Clinical variables associated with colorectal cancer on colonoscopy: a prediction model

The American Journal of Gastroenterology
A ChakG S Cooper

Abstract

We prospectively evaluated the ability of various indications for colonoscopy to predict colorectal cancer. Indications and findings were prospectively recorded for 1223 consecutive colonoscopies performed during an 18-month period at a University Hospital. Colonoscopies performed on 981 patients for indications which included colorectal cancer in the differential diagnosis were included in the study. A group of 653 patients was randomly selected to derive a model predictive of colorectal cancer at colonoscopy; the remaining 328 patients were used to validate the model. Colorectal cancer was found in 44/981 patients (4.5%). Univariate analysis of the derivation set showed that age > 55, occult bleed, anemia, iron deficiency, weight loss, and abnormal CT scan were associated with finding colorectal cancer at colonoscopy in the derivation set, p < 0.05. History of polyps was negatively associated with finding colorectal cancer. Stepwise selection was used to develop a predictive model by using three independent variables-age > 55, iron deficiency, and weight loss. Assigning a score of 1 to each variable, cancer was present in 0% [95% confidence intervals (CI), 0-0.6%], 5.3% (95% CI, 2.3-8.3%), and 17.9% (95% CI, 4.8-31%) of patie...Continue Reading

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
J H Bortz
Arquivos De Gastroenterologia
João Carlos Andreoli, René Lambert
Gastroentérologie Clinique Et Biologique
P StrockA Kerschen
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
W Fasching
© 2021 Meta ULC. All rights reserved