PMID: 16615667Apr 18, 2006Paper

Clinical vs. laboratory identification of drugs of abuse in patients admitted for acute poisoning

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
M A BjornaasD Jacobsen

Abstract

The extent of drug abuse in patients admitted for self-poisonings is uncertain. The aim of this study was to assess the pattern of drugs of abuse among patients admitted for acute poisoning according to age and gender, and to study the concordance between the clinical assessments by the physicians on duty and the drug analyses. Prospective cross sectional study of all patients (n = 405, 52% males, median age 31 years) treated for acute poisoning in our department during one year (2001). The physician on-call classified type of drug of abuse by history and clinical assessment. This was later compared to urine and blood samples analysed for ethanol, benzodiazepines, opiates, cocaine, ecstasy, GHB, amphetamine and cannabis. In 320 admissions (79%), the comparison between clinical diagnosis and laboratory analyses could be performed. A total of 478 drugs were suspected and 621 were found. The main toxic agents found were benzodiazepines (49.7%), ethanol (40.3%), opiates (35.3%), cannabis (23.8%) and amphetamine (21.3%). Ninety-two had used drugs of abuse. The agreement between clinical assessments and laboratory findings was best for GHB and ethanol (kappa = 0.43), and for opiates (k = 0.38). For benzodiazepines and cannabis, the c...Continue Reading

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Citations

Jun 21, 2012·BMC Public Health·Jennifer McNeelyDaliah Heller
Sep 2, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Berit MuanKnut Joachim Berg
Jan 2, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·K E HovdaD Jacobsen
Sep 11, 2008·Emergency Medicine Australasia : EMA·Emma WestAdam Bystrzycki
Oct 21, 2010·The American Journal on Addictions·Raj K Kalapatapu, Maria A Sullivan
Apr 2, 2015·The Journal of Emergency Medicine·Robert Camilleri
Jun 8, 2010·BMC Emergency Medicine·Mari A BjornaasDag Jacobsen
Apr 14, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Odd Martin VallersnesKnut Erik Hovda
May 16, 2008·Human & Experimental Toxicology·F HeyerdahlD Jacobsen
Mar 13, 2015·Iranian Red Crescent Medical Journal·Gulsum KavalciCemil Kavalci

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