Clinical vs Microscopic Extranodal Extension and Survival in Oropharyngeal Carcinoma in the Human Papillomavirus Era

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Thomas J GalBin Huang

Abstract

Extranodal extension (ENE) is known to be associated with poor outcomes in head and neck squamous cell carcinoma. The objective of this study is to examine the impact of extent of ENE on survival in oropharyngeal carcinoma in the human papillomavirus (HPV) era. Retrospective database review. Review of the National Cancer Database. The National Cancer Database was used to examine surgically treated head and neck squamous cell carcinoma of the tonsil and base of tongue from 2010 to 2015. Nodes available for pathologic examination were classified as ENE negative (-), ENE clinically (+), or ENE (+) on pathology only. The primary outcome was overall survival. Cox regression modeling was used to examine the effect of ENE on survival while controlling for patient demographics, HPV status, stage, adjuvant radiation, and chemotherapy. Of the 66,106 patients identified, 16,845 were treated with surgery ± adjuvant therapy, 8780 of whom were known HPV+. Overall 5-year survival for this group was 86%. Documented ENE was associated with over a 60% decrease in survival for clinical (hazard ratio [HR], 1.63) and pathologic (HR, 1.62) ENE compared to negative ENE, after adjustment for stage, adjuvant radiation ± chemotherapy, HPV, and other var...Continue Reading

References

Aug 1, 1985·Archives of Otolaryngology·J T JohnsonP B Thearle
Oct 1, 1985·American Journal of Surgery·R L CarterH J Shaw
Dec 1, 1981·Archives of Otolaryngology·J T JohnsonB A Sigler
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Apr 12, 2001·The New England Journal of Medicine·J MorkJ Dillner
Mar 11, 2003·Cancer·Jayson S GreenbergJeffrey N Myers
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Wei LiBarbara R Rose
May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Jan 10, 2008·Annals of Surgical Oncology·Karl Y BilimoriaClifford Y Ko
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Jun 25, 2009·The Annals of Otology, Rhinology, and Laryngology·Odey C UkpoEric J Moore
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Jun 28, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James S LewisBruce H Haughey
Jun 13, 2012·Seminars in Radiation Oncology·Ranee MehraBarbara Burtness
Feb 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P BossiL Licitra
Jun 2, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Minsu KwonSang Yoon Kim
Nov 7, 2017·Oral Oncology·Gaurav S AjmaniMihir K Bhayani
Jul 11, 2016·Cancers of the Head & Neck·Christopher E Fundakowski, Miriam Lango
May 18, 2019·Journal of Oncology·F De FeliceA Polimeni
Jun 16, 2019·American Journal of Otolaryngology·Bhaswanth DhanireddyThomas J Gal
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P BossiL Licitra

❮ Previous
Next ❯

Citations

Feb 10, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christopher C TsengWayne Daniel Hsueh
May 20, 2021·American Society of Clinical Oncology Educational Book·Shao Hui HuangCarole Fakhry
Sep 29, 2021·Journal of Surgical Oncology·Maelle SalibaBin Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

SAS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.