Clinically accessible cell signaling: second messengers in sepsis and trauma

The Journal of Surgical Research
T F RehringA H Harken

Abstract

Inflammatory mediators of trauma and sepsis transduce cellular events through cell surface receptors initiating intricate membrane and cytosolic reaction cascades that funnel through surprisingly few checkpoints in order to provoke a cellular response. As critical care surgeons, we can explore these cell signalling systems. The purpose of this article is to delineate the six known second messenger pathways relevant to surgical sepsis and trauma. Our comprehension of these signaling systems may offer us an opportunity to blunt post-traumatic cellular injury and promote a constructive response.

Citations

Apr 1, 1996·The Annals of Thoracic Surgery·D R MeldrumA H Harken
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·F J NeumannA Schömig
Nov 7, 2006·The Journal of Pharmacology and Experimental Therapeutics·Basil O IbeJ Usha Raj
Dec 24, 2002·Annals of Surgery·Matthew R RosengartRonald V Maier
Jun 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Martin K AngeleIrshad H Chaudry
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·M R SchäfferA Barbul

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