Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: preclinical validation for clinical translation

Nanomedicine
Kangan LiZhuoli Zhang

Abstract

To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.

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Methods Mentioned

BETA
x-ray angiography
fluorescence-activated cell sorting

Clinical Trials Mentioned

NCT00769106
NCT02008929
NCT01147380
NCT01749865

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