Clinically established biodegradable long acting injectables: An industry perspective.

Advanced Drug Delivery Reviews
Christian Isalomboto NkangaFarshad Ramazani

Abstract

Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.

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Citations

Mar 20, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jack BuftonChristine Allen
May 4, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Lijuan WangYan Liu
May 22, 2021·Advanced Drug Delivery Reviews·Pauric BanniganChristine Allen
Jun 30, 2021·Advanced Drug Delivery Reviews·Sai Archana KroviAriane van der Straten
Jun 29, 2021·Pharmaceutical Development and Technology·Tarek Metwally IbrahimHanan Mohammed El-Nahas
Jul 26, 2021·International Journal of Pharmaceutics·Raghad M AbuhamdanSamer R Abulateefeh
Aug 8, 2021·Advanced Drug Delivery Reviews·Xiaoyi Wang, Diane J Burgess
Sep 1, 2021·Pharmaceutical Research·Sifei HanNatalie Trevaskis

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