PMID: 11316552Apr 24, 2001Paper

Clinically evident fat necrosis in women treated with high-dose-rate brachytherapy alone for early-stage breast cancer

International Journal of Radiation Oncology, Biology, Physics
D E WazerT A DiPetrillo

Abstract

To investigate the incidence of and variables associated with clinically evident fat necrosis in women treated on a protocol of high-dose-rate (HDR) brachytherapy alone without external-beam whole-breast irradiation for early-stage breast carcinoma. From 6/1997 until 8/1999, 30 women diagnosed with Stage I or II breast carcinoma underwent surgical excision and postoperative irradiation via HDR brachytherapy implant as part of a multi-institutional clinical Phase I/II protocol. Patients eligible included those with T1, T2, N0, N1 (< or = 3 nodes positive), M0 tumors of nonlobular histology with negative surgical margins, no extracapsular lymph-node extension, and a negative postexcision mammogram. Brachytherapy catheters were placed at the initial excision, re-excision, or at the time of axillary sampling. Direct visualization, surgical clips, ultrasound, or CT scans assisted in delineating the target volume defined as the excision cavity plus 2-cm margin. High activity (192)Ir (3-10 Ci) was used to deliver 340 cGy per fraction, 2 fractions per day, for 5 consecutive days to a total dose of 34 Gy to the target volume. Source position and dwell times were calculated using standard volume optimization techniques. Dosimetric analys...Continue Reading

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Citations

Sep 28, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·María Concepción López CarrizosaJosé María Delgado Pérez
Jun 26, 2013·Breast Cancer Research and Treatment·Andrea L Russo, Alphonse G Taghian
Feb 9, 2006·Current Oncology Reports·Alphonse G Taghian, Abram Recht
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Michael KirkCam Nguyen
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·David E WazerThomas A DiPetrillo
Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Douglas W ArthurRupert K Schmidt-Ullrich
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Melvin A AstrahanOscar E Streeter
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Harry Bartelink
Nov 19, 2003·Breast Cancer Research and Treatment·J M Hannoun-LeviJ P Gerard
Apr 13, 2004·Annals of Surgery·Henry M KuererFrank A Vicini
Jun 24, 2005·Annals of Surgery·Roland ReitsamerChristian Menzel
Sep 22, 2005·The Breast Journal·Bruce G Haffty
Jun 24, 2006·AJR. American Journal of Roentgenology·Lisa E EssermanMartin E Keisch
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Oct 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Bartelink
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Gregory K EdmundsonAlvaro A Martinez
Apr 6, 2004·Brachytherapy·Beryl C McCormick
May 7, 2011·Journal of Cancer Research and Therapeutics·Akkamma RaviDattatreyudu Nori
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