Clinically normal atopic skin vs. non-atopic skin as seen through electrical impedance

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Ingrid Nicander, Stig Ollmar

Abstract

In an earlier study, we have shown that the electrical impedance (IMP) is dependent on the lipid content of the stratum corneum as studied by lipid extraction. Therefore, we now employ the IMP technique to compare the properties of clinically normal atopic skin with that of non-atopic skin. We looked at the same time at concomitant alterations in transepidermal water loss (TEWL) and skin moisture results. Twenty-two healthy participants and 26 patients with atopic dermatitis were recruited. One test site on each volar forearm was used in the test procedure, of cyclohexane swabbing, skin stripping, and lipid extraction using a mixture of hexane:isopropanol. Responses were evaluated by measuring TEWL, skin moisture using electrical capacitance, and finally IMP spectroscopy in the frequency range 1 kHz to 1 MHz before the start of the study, after each step of the test procedure, and also during a 2 weeks recovery period. Only the IMP results showed significant changes between baseline values of clinically normal atopic skin and healthy skin. Furthermore, IMP and TEWL showed significantly larger reactivity for the atopic group after the skin stripping procedure, and IMP after lipid extraction as well. Our results show that IMP is ...Continue Reading

Citations

Oct 14, 2006·The Journal of Investigative Dermatology·Ivone JakasaSanja Kezic
Feb 6, 2008·The Journal of Allergy and Clinical Immunology·Jayanta GuptaGurjit K Khurana Hershey
Feb 21, 2006·Clinical and Experimental Dermatology·L HagströmerL Emtestam
May 5, 2011·Experimental Dermatology·Peter AbergStig Ollmar
Jun 25, 2010·International Journal of Cosmetic Science·A J Byrne
Dec 21, 2004·IEEE Transactions on Bio-medical Engineering·Peter AbergStig Ollmar
Apr 27, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·E Xhauflaire-UhodaG E Piérard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.