Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Clinical Microbiology Reviews
Laura J V Piddock

Abstract

Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-resistant bacteria. Pumps may be specific for one substrate or may transport a range of structurally dissimilar compounds (including antibiotics of multiple classes); such pumps can be associated with multiple drug (antibiotic) resistance (MDR). However, the clinical relevance of efflux-mediated resistance is species, drug, and infection dependent. This review focuses on chromosomally encoded pumps in bacteria that cause infections in humans. Recent structural data provide valuable insights into the mechanisms of drug transport. MDR efflux pumps contribute to antibiotic resistance in bacteria in several ways: (i) inherent resistance to an entire class of agents, (ii) inherent resistance to specific agents, and (iii) resistance conferred by overexpression of an efflux pump. Enhanced efflux can be mediated by mutations in (i) the local repressor gene, (ii) a global regulatory gene, (iii) the promoter region of the transporter gene, or (iv) insertion elements upstream of the transporter gene. Some data suggest that resistance nodulation division systems are important in pathogenicity and/or survival in a particular ecological niche. Inhibitors...Continue Reading

References

May 1, 1992·Antimicrobial Agents and Chemotherapy·L J PiddockR E Hancock
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A A NeyfakhL B Chen
May 1, 1991·Antimicrobial Agents and Chemotherapy·D M Livermore, K W Davy
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·A A NeyfakhG W Kaatz
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·L J PiddockY F Jin
May 1, 1993·Antimicrobial Agents and Chemotherapy·G W KaatzC A Ruble
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·G W Kaatz, S M Seo
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·H W van VeenW N Konings
Nov 1, 1996·Antimicrobial Agents and Chemotherapy·P N Markham, A A Neyfakh
Apr 1, 1997·Journal of Bacteriology·D G ThanassiH Nikaido
Jun 1, 1997·Antimicrobial Agents and Chemotherapy·N N Baranova, A A Neyfakh
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·M N Alekshun, S B Levy
Jan 7, 1998·Antimicrobial Agents and Chemotherapy·G W Kaatz, S M Seo
Feb 7, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J WainC M Parry
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·P C HsiehK Lewis
Jul 14, 1998·Antimicrobial Agents and Chemotherapy·Y MoritaT Tsuchiya
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·M OethingerS B Levy

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Citations

Jul 4, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M KiB Foxman
Nov 14, 2012·Journal of the American Chemical Society·Francesca ColluPaolo Ruggerone
Jan 10, 2012·Journal of Medicinal Chemistry·John I ManchesterRobert E McLaughlin
Dec 13, 2006·Nature Reviews. Drug Discovery·Olga LomovskayaWilliam J Watkins
Jul 18, 2006·Nature Reviews. Microbiology·Laura J V Piddock
Feb 6, 2007·Nature Reviews. Microbiology·Gerard D Wright
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Klaas M Pos
Jan 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dan I Andersson
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Narisara ChantratitaSharon J Peacock
Mar 28, 2009·The Journal of Biological Chemistry·Alvaro HernándezJosé L Martínez
Nov 28, 2006·Animal Biotechnology·H HarbottleD G White
Dec 17, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Anuj Kumar GuptaVishnu Dutt Sharma
Jun 30, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marija KurinčičSonja Smole Možina
Aug 14, 2008·The Journal of Antimicrobial Chemotherapy·P M Hawkey
Aug 19, 2008·The Journal of Antimicrobial Chemotherapy·J E CorreaP E Jeric
Dec 17, 2009·The Journal of Antimicrobial Chemotherapy·Govindan RajamohanWondwossen A Gebreyes
Mar 23, 2010·The Journal of Antimicrobial Chemotherapy·Laura J V PiddockSimon Gibbons
Jan 8, 2011·The Journal of Antimicrobial Chemotherapy·Vijaya Bharathi SrinivasanWondwossen A Gebreyes
Dec 28, 2010·The Journal of Antimicrobial Chemotherapy·Elena BogatchevaVenkata M Reddy
Jul 19, 2012·The Journal of Antimicrobial Chemotherapy·Nitin Pal KaliaInshad Ali Khan
Apr 15, 2009·Proceedings. Biological Sciences·Jose L Martinez
Mar 14, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Feng LongEdward W Yu
Jan 17, 2012·Photochemistry and Photobiology·Domingo Mariano Adolfo VeraGeorge P Tegos
May 13, 2009·Antimicrobial Agents and Chemotherapy·Ellen Z BaumKaren Bush
Apr 30, 2008·Antimicrobial Agents and Chemotherapy·Yousef M AbouzeedAxel Cloeckaert
Aug 11, 2010·Antimicrobial Agents and Chemotherapy·Jingjing ZhaoJian-Hua Liu
Apr 6, 2011·Antimicrobial Agents and Chemotherapy·Suzanne Bialek-DavenetMarie-Hélène Nicolas-Chanoine
Aug 19, 2009·Antimicrobial Agents and Chemotherapy·Andrea Von GrollPedro Almeida da Silva
Jul 1, 2009·Antimicrobial Agents and Chemotherapy·Santiago Ramón-GarcíaJosé A Aínsa
Oct 6, 2010·Antimicrobial Agents and Chemotherapy·Meenakshi BalganeshUmender Sharma
Sep 23, 2009·Antimicrobial Agents and Chemotherapy·Vijaya Bharathi SrinivasanWondwossen A Gebreyes
Apr 11, 2007·Antimicrobial Agents and Chemotherapy·Anton Y PelegDavid L Paterson

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