Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population

Frontiers in Microbiology
Katharina SchauflerSebastian Guenther

Abstract

High-risk ESBL-producing Enterobacteriaceae (ESBL-E) have been described in wild birds and rodents worldwide. Rats are of special interest not only due to their indicator role for environmental pollution with multi-resistant bacteria but also as possible infection source. Data on the presence of high-risk ESBL-E in urban wildlife from Africa remain scarce, however. Twenty-nine animals from three different rat (Rattus) species were captured in the city of Conakry (Guinea, West Africa) in 2015. Rectal swabs were analyzed for ESBL-E using selective media. Species typing and phenotypic antimicrobial resistance analysis to broad-spectrum beta-lactams and other classes of antimicrobials was performed for Enterobacteriaceae-like isolates using the VITEK®2 system (BioMérieux, Germany). Confirmed ESBL-producing E. coli and K. pneumoniae were whole-genome sequenced and resistance genes, phylogenetic background and genes related to bacterial fitness and virulence were analyzed. In total, six of twenty-nine rats (20%) carried ESBL-E (K. pneumoniae and E. coli). All ESBL-producers were multi-drug resistant with blaCTX-M-15 as the dominating ESBL-type. Interestingly, ESBL-associated clonal lineages E. coli ST38 and K. pneumoniae ST307 were f...Continue Reading

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Citations

Aug 5, 2020·Antimicrobial Agents and Chemotherapy·Gisele PeiranoJohann D D Pitout
Aug 1, 2020·Veterinary Medicine International·Richard OnangaJacques Lebibi
Apr 3, 2019·Veterinary World·Nagham Mohammed AyyalDhuha Ismaeel Abdul-Majeed
Aug 6, 2019·Frontiers in Microbiology·Filipa Trigo da RozaManuela Oliveira
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Mary-Anne FrankMark A Chambers
Mar 14, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Alessandra Tammy Hayakawa Ito de SousaValéria Dutra
Jun 3, 2021·International Journal of Molecular Sciences·Olivia M GrünzweilIgor Loncaric
May 16, 2021·Applied and Environmental Microbiology·Katherine E L Worsley-TonksMeggan E Craft
Jun 22, 2021·Antimicrobial Agents and Chemotherapy·Sophie Alexandra BaronDidier Raoult

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Datasets Mentioned

BETA
PRJNA421654

Software Mentioned

ResFinder
Geneious
Blast Ring Image Generator ( BRIG )
RAST
PlasmidFinder1
NGS
Velvet
Harvest Suite
BLAST
MEGA

Related Concepts

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