Clinically relevant frailty index for mice

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Haiming LiuLaDora V Thompson

Abstract

Frailty is a clinical syndrome associated with the aging process and adverse outcomes. The purpose of this short report was to initiate the development of a Frailty Index in 27- to 28-month-old C57BL/6 mice that matched the clinical criteria used in humans (weakness, slow walking speed, low activity level, poor endurance). The selected criteria included grip strength, walking speed, physical activity, and endurance. The criteria in mice were evaluated by the inverted-cling grip test, rotarod test, voluntary wheel running, and derived endurance scores. Each criterion had a designated cutoff point (1.5 SD below the cohort mean) to identify the mice with the lowest performance. If a mouse presented with three of the criteria scores below the cutoff points, it was identified as frail. Mild frailty was designated if two criteria were below the cutoff points. In this mouse cohort, one mouse was identified as frail and one was mildly frail. This prevalence of 9% frailty is consistent with the prevalence of frailty in humans at the same survival age. Collectively, our selected criterion, cutoff point, and Frailty Index provide a potential standardized definition for frailty in mice that is consistent with the operational definition of ...Continue Reading

References

Jan 1, 1986·Experimental Aging Research·D K Ingram, M A Reynolds
Jan 1, 1982·Experimental Gerontology·D K IngramM A Reynolds
Jan 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A TurturroR W Hart
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jan 30, 2002·Journal of Aging and Health·L M WhetstoneL P Fried
Nov 6, 2003·Age and Ageing·Holly SyddallAvan Aihie Sayer
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Mar 29, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Karen Bandeen-RocheLinda P Fried
Jun 11, 2009·Nature Reviews. Neuroscience·Simon P Brooks, Stephen B Dunnett
Dec 17, 2009·Neurobiology of Aging·Andreas FahlströmBrun Ulfhake
Mar 18, 2011·Journal of the American Geriatrics Society·Laura J ViccaroStephanie A Studenski
Nov 19, 2011·Journal of the American Geriatrics Society·Shelley A SternbergA Mark Clarfield
Jan 11, 2012·Neuroscience and Biobehavioral Reviews·Colleen M NovakJames A Levine
Aug 14, 2012·Journal of the American Geriatrics Society·Rose M CollardRichard C Oude Voshaar
Feb 12, 2013·Lancet·Andrew CleggKenneth Rockwood
Apr 16, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ted G GraberLaDora V Thompson
Jun 15, 2013·Journal of the American Medical Directors Association·John E MorleyJeremy Walston

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Citations

Feb 26, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alice E KaneSarah J Mitchell
Jan 23, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sarah N Hilmer, David G Le Couteur
Sep 9, 2015·Neuroscience and Biobehavioral Reviews·Eric A Rae, Richard E Brown
May 24, 2016·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·John MuscedereUNKNOWN Canadian Frailty Network (CFN)
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James L KirklandFelipe Sierra
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Derek M HuffmanSteven N Austad
Sep 11, 2016·Pathobiology of Aging & Age Related Diseases·Xuan GeWarren Ladiges
Apr 26, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jamie N JusticeChristy S Carter
May 27, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alice E KaneSarah N Hilmer
Jun 22, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Ladd SeldeenBruce Robert Troen
Nov 24, 2017·Frontiers in Medicine·Giuseppe BellelliMatteo Cesari
Mar 22, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ramy K A SayedDarío Acuña-Castroviejo
May 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hye-Na ChaSo-Young Park
Feb 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Smilja T TodorovicSelma D Kanazir
May 3, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Irene Martinez de TodaMonica De la Fuente
May 10, 2016·F1000Research·Simon Melov
Nov 2, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stefano TarantiniAnna Csiszar
Mar 15, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ramy K A SayedDarío Acuña-Castroviejo
May 4, 2017·Canadian Journal of Physiology and Pharmacology·Alice E KaneSusan E Howlett
Feb 25, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cheng Jun JinIna Bergheim
Apr 9, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dongmin KwakLaDora V Thompson
Jul 30, 2019·Aging·Cory W BaumannLaDora V Thompson
Dec 19, 2018·Aging·Cory W BaumannLaDora V Thompson
May 1, 2020·Aging·Laura Pérez-MartínezJosé-Ramón Blanco
Feb 6, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amy YorkeStacy O'Blenes
Jun 28, 2018·Frontiers in Aging Neuroscience·Alice E KaneRichard E Brown
Jun 27, 2019·American Journal of Physiology. Cell Physiology·Donato A RivasRoger A Fielding
Aug 6, 2015·Current Osteoporosis Reports·K L SeldeenB R Troen
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mari Carmen Gomez-CabreraJose Viña
May 13, 2018·Acta Neuropathologica·Rodney M RitzelLouise D McCullough
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marshall G MillerBarbara Shukitt-Hale
May 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alice E Kane, Susan E Howlett
Aug 22, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ted G GraberBlake B Rasmussen
Apr 12, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yosuke YamadaRicki J Colman
Apr 15, 2017·GeroScience·Sathyaseelan S DeepaArlan Richardson
Dec 3, 2016·American Journal of Veterinary Research·Julie HuaLoic Desquilbet
Jun 15, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mariann M GabrawyPeter M Abadir
Dec 15, 2019·Mechanisms of Ageing and Development·Smilja TodorovicAleksandra Mladenovic Djordjevic
Jan 26, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Szczepan W BaranSamuel M Cadena
Feb 26, 2021·GeroScience·Mladen JergovićJanko Nikolich-Žugich

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