Clinically significant association between the maximum standardized uptake value on 18F-FDG PET and expression of phosphorylated Akt and S6 kinase for prediction of the biological characteristics of renal cell cancer

BMC Cancer
Tomoya MizunoKen-Ichiro Yoshida

Abstract

The relationship between the clinicopathological features and molecular changes associated with standardized uptake value (SUV) determined by Positron emission tomography (PET) with [18F] fluorodeoxyglucose (18F-FDG PET) in human renal cell carcinoma (RCC) has not been elucidated. On the other hand, overactivation of the phosphatidylinositol 3'kinase (PI3K), serine/threonine kinase Akt, and mammalian target of rapamycin (mTOR) pathway has been detected in a variety of human cancers, including RCC. So far, little is known about the relationship between the SUV and these proteins in human RCC. Thus, it is important to study the relevance of SUV with clinicopathological features in human RCCs from a molecular point of view. Seventy-seven consecutive patients with RCC who underwent nephrectomy and pretreatment determination of the maximum SUV (SUVmax) by 18F-FDG PET were analyzed. We investigated the relationship between the SUVmax, phosphorylated-Akt (Ser-473) (pAkt(Ser-473)), phosphorylated-Akt (Thr-308) (pAkt(Thr-308), and phosphorylated-S6 ribosomal protein (Ser-235/236) (pS6) protein levels in the primary tumor and various clinicopathological features. The average SUVmax of the primary tumor was 6.9 (1.5 to 40.3). A higher SUV...Continue Reading

References

Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
Sep 19, 1996·The New England Journal of Medicine·R J MotzerD M Nanus
May 20, 2004·Cancer Research·Andrew M ArshamM Celeste Simon
Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Sep 20, 2005·Cancer Cell·Nissim Hay
Dec 13, 2005·The New England Journal of Medicine·Herbert T Cohen, Francis J McGovern
Dec 13, 2005·Nature Medicine·George V ThomasCharles L Sawyers
May 22, 2008·AJR. American Journal of Roentgenology·Kazuhiro KitajimaKazuro Sugimura
Oct 24, 2008·The Journal of Biological Chemistry·Alfredo ToschiDavid A Foster
Apr 22, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wen Wee MaManuel Hidalgo
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Jul 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kyoichi KairaNobuyuki Yamamoto
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Jul 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irfan KayaniThomas Powles
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Robert A FiglinJillian Brechbiel
May 2, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Marston Linehan, Tracey A Rouault

❮ Previous
Next ❯

Citations

Apr 6, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J Vlachostergios, A M Molina
May 10, 2017·Nature Reviews. Nephrology·Hiromi I WetterstenRobert H Weiss
Feb 22, 2018·Cancer Chemotherapy and Pharmacology·Noboru NakaigawaMasahiro Yao
May 30, 2020·Journal of Clinical Pathology·Raviprakash Tumkur SitaramBörje Ljungberg
May 26, 2016·Japanese Journal of Radiology·Kazuhiro KitajimaHossein Jadvar
Jan 11, 2017·Journal of Medical Imaging and Radiation Oncology·Alessia MennittoGiuseppe Procopio
Nov 30, 2018·Clinical and Experimental Medicine·Violetta PankowskaKrzysztof Roszkowski

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

AZE Virtual Place
ImageJ
NIH Image

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.