PMID: 3877075Nov 1, 1985

Clinically significant cross-reactions with counterimmunoelectrophoresis between pneumococcus type 6 and Haemophilus influenzae type b

Journal of Clinical Microbiology
T L BallardM P Glode

Abstract

Biologically and clinically significant cross-reactions may occur between the immunochemically similar capsule antigens of Haemophilus influenzae type b and Streptococcus pneumoniae type 6 by using counterimmunoelectrophoresis (CIE). In three cases of culture-proven S. pneumoniae type 6 disease, a false-positive H. influenzae type b CIE result was detected in a body fluid. Two of three cases were also positive when tested by CIE with pneumococcal omnisera. However, in one of the culture-proven cases of pneumococcal type 6 disease, the omniserum was negative and only the burro 132 H. influenzae type b antiserum demonstrated a positive precipitant reaction. In addition to the three case isolates, we evaluated nine blood or cerebrospinal fluid isolates of pneumococcus type 6, using a variety of both species- and type-specific antisera, by CIE. Two burro antisera detected 12 of 12 (100%) of the S. pneumoniae type 6 strains. A rabbit H. influenzae type b antiserum did not detect any (0 of 12; 0%) of the S. pneumoniae type 6 strains evaluated. All (12 of 12; 100%) of the S. pneumoniae type 6 strains were detected with both rabbit omniserum (S. pneumoniae) and rabbit type 6 antiserum. Our data illustrate the importance of being aware ...Continue Reading

Citations

Nov 1, 1988·Clinical Pediatrics·H Peltola, M Jaakkola
Oct 22, 2013·Arquivos de neuro-psiquiatria·Maristela Marques SalgadoCláudio Tavares Sacchi

Related Concepts

Antigens, Bacterial
Cross Reactions
Haemophilus influenzae
Immunoelectrophoresis, Two-Dimensional
Streptococcal Pneumonia
Streptococcus pneumoniae

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