Sep 29, 2011

Clinically significant drug interactions with antacids: an update

Drugs
Ryuichi Ogawa, Hirotoshi Echizen

Abstract

One may consider that drug-drug interactions (DDIs) associated with antacids is an obsolete topic because they are prescribed less frequently by medical professionals due to the advent of drugs that more effectively suppress gastric acidity (i.e. histamine H(2)-receptor antagonists [H2RAs] and proton pump inhibitors [PPIs]). Nevertheless, the use of antacids by ambulant patients may be ever increasing, because they are freely available as over-the-counter (OTC) drugs. Antacids consisting of weak basic substances coupled with polyvalent cations may alter the rate and/or the extent of absorption of concomitantly administered drugs via different mechanisms. Polyvalent cations in antacid formulations may form insoluble chelate complexes with drugs and substantially reduce their bioavailability. Clinical studies demonstrated that two classes of antibacterials (tetracyclines and fluoroquinolones) are susceptible to clinically relevant DDIs with antacids through this mechanism. Countermeasures against this type of DDI include spacing out the dosing interval - taking antacid either 4 hours before or 2 hours after administration of these antibacterials. Bisphosphonates may be susceptible to DDIs with antacids by the same mechanism, as d...Continue Reading

  • References87
  • Citations8

References

Mentioned in this Paper

Tetracycline Antibiotics
Fluoroquinolones
Diphosphonates
Cations
Drug Interactions
Pharmaceutical Preparations
Thrombopoietin Receptor Agonist [EPC]
Antacids
Histamine
Drugs, Non-Prescription

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