Clinically significant interactions of psychotropic agents with antipsychotic drugs

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
M C MeyerF Centorrino

Abstract

Various psychotropic drugs are commonly combined with antipsychotic agents. Such combinations can induce pharmacodynamically based, presumably additive, beneficial (e.g. sedative or mood-altering) effects or adverse autonomic, cardiac depressant and CNS intoxicating effects. Clinically significant interactions also arise through competition with or induction of hepatic microsomal cytochrome P450 (CYP) enzymes, particularly the CYP1A2 and CYP2D6 isozymes by which most antipsychotics are oxidised. Such pharmacokinetic interactions can elevate circulating concentrations of antipsychotics (both typical agents and the atypical antipsychotic clozapine) to potentially toxic ranges, which may lead to increased risks of adverse effects. Such interactions occur particularly with serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor antidepressants. Metabolic interactions that lead to lesser increases in antipsychotic concentrations may arise in combining these drugs with other antidepressants, benzodiazepines or propranolol. In contrast, most anticonvulsants, except valproic acid (sodium valproate), induce the oxidative metabolism of antipsychotics and can lower their plasma concentrations to potentially subtherapeutic levels, with un...Continue Reading

Citations

Jan 13, 1999·Pediatric Clinics of North America·A P Ten EickM D Reed
Apr 20, 2000·British Journal of Clinical Pharmacology·K D WilnerN Gerber
Sep 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·E DongA Guidotti
Mar 17, 2001·International Clinical Psychopharmacology·J Kane
Dec 13, 2005·Clinical Neuropharmacology·Chanoch MiodownikVladimir Lerner
Jun 4, 2008·Clinical Neuropharmacology·Chanoch MiodownikVladimir Lerner
Jan 13, 2004·Clinical Pharmacokinetics·Candace S BrownSamantha F Eichner
Aug 11, 2004·Clinical Pharmacokinetics·Guillermo GervasiniJulio Benitez
Apr 20, 2000·British Journal of Clinical Pharmacology·G ApseloffN Gerber
Apr 20, 2000·British Journal of Clinical Pharmacology·J J MiceliA Laurent
Dec 28, 1999·Epilepsia·F Monaco, A Cicolin
Feb 20, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dallas R DonohoeDonard S Dwyer
Nov 30, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yi-Ling HsiaoShao-Tsu Chen
Aug 5, 1998·Journal of Clinical Psychopharmacology·J A CarrilloJ Benítez
Mar 3, 2010·Human Psychopharmacology·Franca CentorrinoRoss J Baldessarini
Sep 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·N A Buckley, P Sanders
Dec 20, 2007·Expert Review of Neurotherapeutics·Maurizio PompiliPaolo Girardi
May 1, 1997·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·D M GardnerM Tohen
Jun 18, 2004·Thérapie·Christian LibersaJacques Caron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Care : the Official Journal of the Critical Care Forum
Robert J Devlin, John A Henry
Trends in Pharmacological Sciences
Andrew G Ramage, Carlos M Villalón
© 2021 Meta ULC. All rights reserved