Clinically significant sub-clonality for common drivers can be detected in 26% of KRAS/EGFR mutated lung adenocarcinomas

Oncotarget
Einav SimonDov Hershkovitz

Abstract

Genetic sub-clonality has been described in multiple malignancies, however the presence of sub-clonality for major drivers in lung adenocarcinoma and its clinical significance is a subject under debate. Using molecular and morphometric approach, 347 lung adenocarcinoma samples were analyzed for KRAS and EGFR sub-clonality, which was further correlated with clinical and pathological variables.KRAS and EGFR mutations were identified in 100 (29%) and 82 (23%) cases, respectively. One hundred and forty four KRAS or EGFR positive cases were also available for morphometric analysis, among which 37 (26%) were defined as sub-clonal. The presence of sub-clonality was associated with shorter survival time (p=0.02). Interestingly, cases with sub-clonality were also associated with earlier disease stage (89% vs 66% stage I disease in sub-clonal vs clonal cases, respectively, p=0.01) and less lymph node involvement (8% vs 25% in sub-clonal vs clonal cases, respectively, p=0.02). Our findings demonstrate the presence of sub-clonality for mutations in common drivers in lung adenocarcinoma and link it both to earlier disease stage and to poor survival. These findings are in line with the different evolutionary models that can present with gene...Continue Reading

References

Dec 15, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hidefumi SasakiYoshitaka Fujii
Jan 12, 2011·Nature Biotechnology·James T RobinsonJill P Mesirov
Jul 7, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yasushi YatabeTetsuya Mitsudomi
Jul 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qing ZhouYi-Long Wu
Jan 1, 2010·Cancer Biomarkers : Section a of Disease Markers·Edna EfratiDov Hershkovitz
Oct 22, 2011·Virchows Archiv : an International Journal of Pathology·Liora FarberDov Hershkovitz
Dec 2, 2011·Cancer Chemotherapy and Pharmacology·Jan Nyrop Jakobsen, Jens Benn Sørensen
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Jul 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hua BaiJie Wang
Oct 25, 2012·Annual Review of Pathology·Vanessa AlmendroKornelia Polyak
Jun 22, 2013·Clinical Lung Cancer·Nanae TomonagaShigeru Kohno
Oct 12, 2013·The Journal of Pathology·Andrew CrockfordCharles Swanton
Jan 31, 2014·Cancer Cytopathology·Francisco Beca, Fernando Schmitt
Mar 25, 2014·Current Opinion in Genetics & Development·Rebecca A Burrell, Charles Swanton
Apr 22, 2014·Annals of Surgical Oncology·Shih-Ping ChengJie-Jen Lee
Jul 8, 2014·Human Pathology·Dov HershkovitzMichael Vieth
Aug 5, 2014·Molecular Oncology·Rebecca A Burrell, Charles Swanton
Aug 17, 2014·The American Journal of Pathology·Juan LinSimon D Spivack
Dec 3, 2014·Clinical Lung Cancer·Youngjoo LeeJin Soo Lee
Jan 15, 2015·Cancer Cell·Nicholas McGranahan, Charles Swanton
Mar 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mariam Jamal-HanjaniCharles Swanton
Sep 30, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Weijing CaiFred R Hirsch
Feb 2, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qiang TanShun Lu
Feb 3, 2016·The Journal of Clinical Endocrinology and Metabolism·Alona FinkelDov Hershkovitz
Apr 2, 2016·Oncotarget·Levi G LedgerwoodSufi Mary Thomas

❮ Previous
Next ❯

Citations

Dec 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hua-Li LiuQi-Bin Song
Nov 21, 2019·American Journal of Respiratory and Critical Care Medicine·Jun QianPierre P Massion
Sep 30, 2021·Journal of Clinical Pathology·Michael J AllenGrainne M O'Kane

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
chip

Software Mentioned

Image Pro Plus
Integrative Genomic Viewer ( IGV
Torrent Suite
integrative browser
Ion Torrent

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Katharina SchmidMartin Filipits
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Frank SchneiderSanja Dacic
© 2022 Meta ULC. All rights reserved