PMID: 3767150Nov 1, 1986Paper

Clinically silent atrial septal defects with evidence for cerebral embolization

Annals of Internal Medicine
J R HarveyU Thadani

Abstract

The cause of stroke in young patients frequently cannot be established. Eleven consecutive patients, age 50 and younger, had clinical evidence of cerebral embolization. Results of physical, radiographic, electrocardiographic, and two-dimensional echocardiographic examinations were normal in all patients. During normal respiration, eight of the patients had right-to-left shunts at the atrial level shown by microcavitation contrast two-dimensional echocardiography. Six of the eight patients with positive contrast studies had cardiac catheterization. Five of six patients had an atrial septal defect, normal right and left heart pressures, and small right-to-left shunts during a Valsalva strain. Four patients had surgical closure of the defect, which ranged in size from 5 to 10 mm. The remaining patients received anticoagulants. Interatrial communications appear to be common in young patients with stroke, suggesting paradoxical embolization as a possible mechanism. Contrast two-dimensional echocardiography should be done in such patients because it is the only noninvasive technique that reliably finds these defects.

Citations

Aug 16, 1991·Klinische Wochenschrift·S KonstantinidesH Just
Apr 1, 1994·Italian Journal of Neurological Sciences·C GandolfoE Moretti
May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D H Wong
Oct 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W H Noble, J St-Amand
Dec 20, 2003·Current Neurology and Neuroscience Reports·Carlos J Rodriguez, Shunichi Homma
May 1, 1992·Journal of the American College of Cardiology·P SiostrzonekH Mösslacher
Jun 17, 1998·Journal of Internal Medicine·J R BeattieP S Douglas
Aug 2, 2001·Internal Medicine Journal·D McGaw, R Harper
Oct 1, 1990·Australian and New Zealand Journal of Medicine·M W Webster, D N Sharpe
May 1, 1996·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O MiróF Cardellach
Apr 6, 1991·BMJ : British Medical Journal·J Bolo-Deoku, P N Fison
Mar 1, 1993·International Journal of Cardiac Imaging·M Di TullioS Homma
Sep 1, 1994·International Journal of Cardiac Imaging·M A DeGeorgiaW F Armstrong
Feb 5, 2004·Current Cardiology Reports·Carlos J Rodriguez, Shunichi Homma
May 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·D C Berkompas, K B Sagar
May 12, 2001·Chest·B W HolcombI M Robbins
Jan 1, 1991·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·C R Gomez, A J Labovitz
Jan 1, 1992·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·L Y TsaoB A Evans
Sep 4, 2007·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Yves L BayardHorst Sievert
Aug 18, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·S-C YapUNKNOWN ZAHARA investigators
Apr 30, 2005·International Journal of Cardiology·Herwig Walter SchuchlenzReinhold Schmidt
May 15, 1992·The American Journal of Cardiology·M A de BelderA J Camm
Dec 15, 1993·The American Journal of Cardiology·A J LabovitzC R Gomez
Oct 22, 2010·The American Journal of Medicine·James E DalenFadi Matta
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Birke Schneider, Rudolf Bauer
Jan 15, 1995·The American Journal of Cardiology·V SansoyS Kaul
Oct 1, 1988·The American Journal of Cardiology·A MüggeP R Lichtlen
Sep 24, 2016·Journal of Vascular and Interventional Radiology : JVIR·Jeffrey Forris Beecham ChickScott O Trerotola
Aug 1, 1992·Angiology·J SchwartzB Habot
Dec 1, 1989·Annals of Neurology·E B RingelsteinC Minale
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M Di TullioS Homma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.