PMID: 8983676Oct 1, 1996Paper

Clinically stable angina pectoris is not necessarily associated with histologically stable atherosclerotic plaques

Heart
A C van der WalG K David

Abstract

To investigate the extent of plaque inflammation in culprit lesions of patients with chronic stable angina. Retrospective study. Amsterdam reference centre. 89 consecutive patients who underwent directional coronary atherectomy, 58 of whom met the following inclusion criteria: chronic stable angina (Canadian Cardiovascular Society classification 1-3 (group 1, n = 28)); unstable angina (Braunwald class II (group 2, n = 18)); unstable angina (Braunwald class III (group 3, n = 12)). Directional atherectomy in patients with angina pectoris. Tissue areas of culprit lesions occupied by inflammatory cells and smooth muscle cells related to clinically defined ischaemic syndrome. Areas (% of total surface area (mean (SEM)) rich in smooth muscle cells were larger in patients with chronic stable angina (group 1, 51.2 (20.9)) than in those with unstable angina (group 2, 42.1 (20.5); group 3, 29.5 (19.4)) (1 v 2 and 2 v 3, NS; 1 v 3, P < 0.004). Macrophage rich areas were significantly smaller in patients with stable angina (group 1, 21.8 (11.9)) than in those with unstable angina (group 2, 31.5 (14.6); group 3, 46.4 (16.7)) (1 v 2, P < 0.02; 2 v 3, P < 0.02; 1 v 3, P < 0.001). Mean numbers of T cells per mm2 were as follows: group 1, 17 (9...Continue Reading

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Citations

Apr 13, 2001·Journal of the American College of Cardiology·S KennonA D Timmis
Jun 27, 2002·Journal of the American College of Cardiology·Michael R CusackSimon R Redwood
Sep 19, 1998·Journal of the American College of Cardiology·M KaartinenP T Kovanen
Nov 11, 1998·Journal of the American College of Cardiology·G CaligiuriA Maseri
Mar 25, 2000·Journal of the American College of Cardiology·J J PiekA E Becker
Dec 18, 2012·European Heart Journal·Erling FalkRenu Virmani
Oct 28, 2010·Journal of Cardiothoracic Surgery·Jorge Chiquie BorgesJose A F Ramires
Jun 17, 2010·Biomarkers in Medicine·Olivier MullerJozef Bartunek
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Mar 18, 2005·International Journal of Cardiology·Carlos V SerranoJosé Antonio F Ramires
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Oct 28, 1999·American Heart Journal·E Falk
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Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Paul CullenUNKNOWN MAFAPS Consortium

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