Clinically useful prediction of hospital admissions in an older population

BMC Geriatrics
Jan MarcussonJohan Lyth

Abstract

The healthcare for older adults is insufficient in many countries, not designed to meet their needs and is often described as disorganized and reactive. Prediction of older persons at risk of admission to hospital may be one important way for the future healthcare system to act proactively when meeting increasing needs for care. Therefore, we wanted to develop and test a clinically useful model for predicting hospital admissions of older persons based on routine healthcare data. We used the healthcare data on 40,728 persons, 75-109 years of age to predict hospital in-ward care in a prospective cohort. Multivariable logistic regression was used to identify significant factors predictive of unplanned hospital admission. Model fitting was accomplished using forward selection. The accuracy of the prediction model was expressed as area under the receiver operating characteristic (ROC) curve, AUC. The prediction model consisting of 38 variables exhibited a good discriminative accuracy for unplanned hospital admissions over the following 12 months (AUC 0.69 [95% confidence interval, CI 0.68-0.70]) and was validated on external datasets. Clinically relevant proportions of predicted cases of 40 or 45% resulted in sensitivities of 62 and...Continue Reading

References

Jun 3, 1988·Science·J A Swets
Sep 29, 2004·American Journal of Public Health·Annette L FitzpatrickJohn A Robbins
Dec 24, 2009·BMJ : British Medical Journal·Joanna CollertonThomas B L Kirkwood
Nov 26, 2010·The European Journal of General Practice·Giancarlo Lucchetti, Alessandra L Granero
Mar 16, 2011·Ageing Research Reviews·Alessandra MarengoniLaura Fratiglioni
Oct 20, 2011·JAMA : the Journal of the American Medical Association·Devan KansagaraSunil Kripalani
Apr 19, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Leocadio Rodríguez-MañasUNKNOWN FOD-CC group (Appendix 1)
May 15, 2013·Age and Ageing·Franklin WouSimon Paul Conroy
Jun 15, 2013·Journal of the American Medical Directors Association·John E MorleyJeremy Walston
Feb 24, 2015·Journal of the American Medical Directors Association·Anne W EkdahlPer Carlsson

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Software Mentioned

R
Elastic Regularized Generalized Linear Models ( glmnet )
Modern Applied Statistics with S ( MASS )
pROC
Regression Modeling Strategies ( rms )
Lasso

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