Clinically useful predictors of conversion to abnormal glucose tolerance in women with polycystic ovary syndrome

Fertility and Sterility
Marie-Hélène Pesant, Jean-Patrice Baillargeon

Abstract

To determine clinically useful predictors of conversion from normal to abnormal glucose tolerance (AGT) in women with polycystic ovary syndrome (PCOS) during regular follow-up, considering that optimal timing for retesting with an oral glucose tolerance test (OGTT) is unknown. Retrospective cohort study. Reproductive endocrinology clinic of an academic center. Glucose-tolerant PCOS women having a follow-up OGTT≥1 year later. Regular clinical follow-up. Sets of criteria associated with the lowest false negative rate and an optimal specificity. Out of 83 women with PCOS, 24.1% converted to AGT during a median follow-up of 3.0 years, including 3.6% who converted to diabetes. Conversion to AGT was significantly associated with glucose excursion and 2-hour glucose during the normal OGTT, increase in fasting glucose (FG) and body mass index during follow-up, and homeostasis model-assessment insulin resistance and FG at follow-up. The best predictive set of criteria was a baseline glucose excursion of >25 mg/dL or an increase in FG of ≥5%. Using these criteria would have saved 45% of the OGTTs, without missing any conversion to AGT. Although our results need to be validated, we determined that using glucose excursion during the previo...Continue Reading

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Citations

Jan 27, 2012·Reproductive Biology and Endocrinology : RB&E·Hua-Ling ZhaiYing-Li Lu
May 19, 2012·Journal of Midwifery & Women's Health·Maureen Shannon, Yusharn Wang
Jul 5, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jing GaoChen Chen
Aug 9, 2018·Diabetes/metabolism Research and Reviews·Małgorzata Jacewicz-Święcka, Irina Kowalska
Oct 16, 2012·Endocrine Reviews·Evanthia Diamanti-Kandarakis, Andrea Dunaif
Nov 1, 2013·Expert Review of Endocrinology & Metabolism·Paolo Moghetti, Flavia Tosi
Oct 24, 2020·Journal of Clinical Medicine·Małgorzata Jacewicz-Święcka, Irina Kowalska
Dec 29, 2016·Open Access Macedonian Journal of Medical Sciences·Sasha Jovanovska-MishevskaBrankica Krstevska

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