Abstract
The aim of this retrospective analysis is to reveal clinicopathological findings and clinical outcome of patients with stage IB1/IB2 (FIGO 2018) uterine cervical cancer. Based on the database of the Japanese Gynecologic Oncology Group, 2194 patients with stage IB1/IB2 (FIGO 2018), who underwent radical hysterectomy between 1/1/2004-12/31/2008, were identified as eligible for this retrospective study. Patients with squamous cell carcinoma had significantly frequent lympho-vascular space invasion than those with non-squamous cell carcinoma in both stage IB1 and IB2 (stage IB1; 29.1% vs. 17.1%, p < 0.0001, stage IB2; 50.5% vs. 39.7%, p = 0.0009). Among 1262 patients with stage IB1, 61.2% (772/1262) were low-risk group, 29.4% (371/1262) were intermediate-risk group (single risk: 23.3%, double risks: 6.1%). Of 932 patients with stage IB2, 32.1% (299/932) were low-risk group, 59.1% (551/932) were intermediate-risk group (single intermediate-risk: 31.0%, double intermediate-risk: 28.1%). Disease-free survival rate and overall survival rate of stage IB1 patients were significantly better than those with stage IB2 (5-year DFS; 94.7% vs. 88.6%, p < 0.001, 5-yrs OS; 98.5% vs. 95.1%, p < 0.001). Stage IB1 Patients with double intermediate-...Continue Reading
References
May 16, 1998·Virchows Archiv : an International Journal of Pathology·K IshiiT Katsuyama
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Apr 15, 1999·The New England Journal of Medicine·H M KeysD Gersell
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C W WhitneyS Y Liao
Oct 4, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T IrieN Terakawa
May 15, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yoshiki MikamiHiroshi Naganuma
Apr 27, 2007·The American Journal of Surgical Pathology·Atsumi KojimaRyuichiro Nishimura
Aug 24, 2010·Histopathology·Oisin HoughtonW Glenn McCluggage
Sep 11, 2010·The American Journal of Pathology·Yasuki KusanagiRyuichiro Nishimura
Apr 15, 2011·The American Journal of Surgical Pathology·Kay J ParkEdyta C Pirog
Jan 24, 2012·Gynecologic Oncology·Vijaya GalicJason D Wright
Feb 2, 2012·Gynecologic Oncology·Kanyarat KatanyooSumonmal Manusirivithaya
Mar 19, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN FIGO Committee on Gynecologic Oncology
Mar 22, 2014·Molecular and Clinical Oncology·Muneaki ShimadaJunzo Kigawa
Feb 11, 2015·Gynecologic Oncology·Tomoyasu KatoUNKNOWN Gynecologic Oncology Study Group of the Japan Clinical Oncology Group
Jun 23, 2015·International Journal of Cancer. Journal International Du Cancer·Katsiaryna HollDavid Jenkins
Oct 13, 2015·The American Journal of Surgical Pathology·Yevgeniy S KaramurzinKay J Park
Dec 6, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Atsumi KojimaUNKNOWN Sankai Gynecology Study Group
Oct 7, 2018·International Journal of Clinical Oncology·Yasuhiko EbinaDaisuke Aoki
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Neerja BhatlaRengaswamy Sankaranarayanan
Nov 1, 2018·The New England Journal of Medicine·Alexander MelamedJ Alejandro Rauh-Hain
Nov 1, 2018·The New England Journal of Medicine·Pedro T RamirezAndreas Obermair
Nov 6, 2018·Gynecologic Oncology·Koji MatsuoMikio Mikami
Feb 3, 2019·Gynecologic Oncology·Shin NishioToshiharu Kamura
May 28, 2019·Cancer Management and Research·Ding-Ding YanXiao-Juan Lv
May 29, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Oct 9, 2019·Oncology·Amelie de GregorioNikolaus de Gregorio
Dec 10, 2019·The Lancet Global Health·Marc ArbynFreddie Bray
Dec 18, 2019·Histopathology·Yoshiki Mikami