Clinico-Pathological Characteristics of Triple Negative and Non Triple Negative High Grade Breast Carcinomas with and Without Basal Marker (CK5/6 and EGFR) Expression at a Rural Tertiary Hospital in India.

Breast Cancer : Basic and Clinical Research
Chidambharam ChoccalingamSruti Rao

Abstract

Aims of the study were to evaluate the expression Cytokeratin 5/6(CK5/6) and Epidermal Growth Factor Receptor (EGFR) among triple negative breast cancers and high grade infiltrating duct carcinomas. Further to probe if triple negative phenotype can be a surrogate marker for basal phenotype and to correlate the expression of basal markers with disease free survivals among triple negative phenotype and high grade infiltrating duct carcinomas. Expression of CK5/6 and EGFR were studied by Immunohistochemistry (IHC) in 31 triple negative and 19 non-triple negative high grade breast carcinomas. 21 of the 31 triple negative phenotype (67.7%) breast carcinomas and 7 out of 19 non-triple negative (36.8%) breast carcinomas showed expression of basal markers (CK5/6 and/or over-expression of EGFR). There were statistically significant associations of all the basal-like tumors with negative hormonal status. The basal markers positive phenotype subjects had a shorter disease free interval as compared to basal markers negative phenotype subjects. Basal-like breast carcinomas constitute a unique clinical and pathological entity, characterized by high tumor grade and a propensity for lack of ER, PR and HER2 expression. Basal phenotypes have a m...Continue Reading

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Citations

Mar 22, 2013·Breast Cancer : Basic and Clinical Research·Kristiina JoensuuPäivi Heikkilä
Nov 26, 2013·Ultrasound in Medicine & Biology·Woo Jung ChoiMin Ji Hong
Sep 30, 2015·Journal of Laboratory Physicians·Arathi A ChangaviAshwini S Ramji
Aug 21, 2013·The Breast : Official Journal of the European Society of Mastology·Giuseppe CuriglianoAron Goldhirsch
Dec 3, 2014·Molecular Oncology·Christiana S KapplerStephen P Ethier
Nov 10, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Qiang GuoJiawei Tian
Nov 6, 2015·PloS One·Paolo Cossu-RoccaMaria Rosaria De Miglio
Feb 6, 2017·Endocrine-related Cancer·Jenny G Parvani, Mark W Jackson
Nov 24, 2019·Cancers·Amaia Eleonora MaennlingAhmad Fawzi Hussain

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