Clinico-pathological effects of Schistosoma mansoni infection associated with simultaneous exposure to malathion in Swiss outbred albino mice

Acta Tropica
H M ElsheikhaMohammad H Rahbar

Abstract

To investigate whether infection of Swiss outbred mice with the digenetic fluke Schistosoma mansoni is influenced by exposure to environmental pollutants, experimentally infected mice were exposed to 200 and 400 mg/kg of malathion. Pathology of liver and spleen, worm burden and levels of key hematological, biochemical and liver enzymes parameters of these mice were evaluated and were compared with data from infected, unexposed mice, uninfected, exposed mice as well as with data from uninfected, unexposed mice. Oral administration of malathion to mice infected with 20, 40 or 60 S. mansoni cercariae adversely affect architecture of liver and spleen and critically alter hematological, biochemical, histological and hepatic enzymes parameters significantly more than the controls. Alterations observed in infected, exposed mice included (i) higher mortality rate; (ii) severe pathologies in liver and spleen; (iii) increased serum level of bilirubin and alanine aminotransferase/aspartate aminotransferase (ALT/AST) enzymes; (iv) decreased serum level of albumin and total proteins; and (v) decreased red blood cell count (RBC), lymphocytes, leucocytic count, and hemoglobin content. The number of recovered adult worms of S. mansoni or their...Continue Reading

References

Dec 1, 1993·Journal of Pharmacological and Toxicological Methods·D Parent-Massin, D Thouvenot

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Citations

May 27, 2009·Parasitology Research·Nashwa A ElsaiedHany M Elsheikha
Feb 19, 2020·Phytotherapy Research : PTR·Muhammad Torequl IslamJavad Sharifi-Rad
Dec 6, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Fabiana Letícia da SilvaFred Luciano Neves Santos

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