Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer

PloS One
Yuichiro MikiMasaichi Ohira

Abstract

It has been reported that CD63, an exosome marker, is expressed in solid cancer tissues. However, its significance in patients with gastric cancer has not been clarified. Exosomes derived from cancer cells and stromal cells might play an important role in the intracellular communications involved in the development of carcinoma. This study aimed to clarify the relationship between CD63 expression in cancer cells and stromal cells and clinical-pathologic factors. A total of 595 gastric cancer patients were enrolled in this study. CD63 expression in cancer cells and stromal cells was analyzed by immunohistochemistry. The correlations between CD63 expression and several clinicopathological factors were investigated. CD63 expression was mainly observed on the cell membranes of cancer cells, and in the cytoplasm of stromal cells. Of 595 patients, 247 cases had CD63-positive cancer cells, and 107 cases had CD63-positive stromal cells. Cases with CD63-positive cancer cells were significantly correlated with scirrhous-type gastric cancer, tumor depth, lymph node metastasis, lymphatic invasion, and tumor size. Cases with CD63-positive stromal cells were significantly correlated with age (≥65), tumor depth (T3-4), lymphatic invasion, and...Continue Reading

References

Dec 25, 2012·Blood Reviews·Yuana YuanaRienk Nieuwland
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Mar 11, 2018·BMC Cancer·Charlotte Aaberg-JessenBjarne W Kristensen

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Citations

Feb 5, 2019·Cancer Metastasis Reviews·Mariantonia LogozziStefano Fais
Jun 13, 2020·International Journal of Molecular Sciences·Bianka BojkováMagdalena Wszedybyl-Winklewska
Feb 14, 2021·Medicine·Jinlong ZhangHaijin Chen
Apr 6, 2021·Veterinary Pathology·Laura BongiovanniAlain de Bruin
Jun 11, 2021·Frontiers in Oncology·Jing GaoLian Liu
Jul 27, 2021·Expert Review of Molecular Diagnostics·Raheleh HeydariAnna Meyfour

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