Clinico-Pathological Study of 4 Cases of Pseudoherpetic Grover Disease: The Same as Vesicular Grover Disease

The American Journal of Dermatopathology
Tania M CapusanMar Llamas-Velasco

Abstract

Grover disease (GD) was described with 4 histopathological patterns, but later wide histopathological studies found additional ones including vesicular GD. From 2014, 2 new patterns, GD with epidermolytic hyperkeratosis and pseudoherpetic GD, have been proposed. The authors present 4 cases of pseudoherpetic GD and review the 6 previously published cases to better characterize this variant clinically and histopathologically. Half of the patients were men. Mean age at diagnosis was 70, 25 years old. All the patients were immunosuppressed, and 75% of them were treated with chemotherapy. Lesions were asymptomatic or itchy papules sometimes crusted and intermingled with isolated vesicles or pustules mostly in the trunk. Skin biopsies showed intraepidermal vesicles filled with plasma (50%) with floating grouped acantholytic cells. No viral inclusions were found, and immunostaining for herpes virus and varicella zoster was negative. Vesicular pattern in GD is described exclusively from a histopathological point of view, and it is defined as the presence of an intraepidermal vesicle filled with plasma and with dyskeratotic cells in the upper part of the vesicle. After reviewing all the described cases, pseudoherpetic GD presents the sa...Continue Reading

References

Jun 8, 2010·The American Journal of Dermatopathology·María-Teresa Fernández-FiguerasAurelio Ariza
Sep 28, 2012·The Australasian Journal of Dermatology·Penelope Am Bunce, Duncan G Stanford
Feb 26, 2013·The American Journal of Dermatopathology·Jessica N BeardenClay J Cockerell
May 17, 2013·The American Journal of Dermatopathology·Ginger L WiersmaGeorge F Murphy
Dec 2, 2014·The American Journal of Dermatopathology·Maria-Teresa Fernández-FiguerasAurelio Ariza

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Citations

Aug 9, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Francesco BellinatoGiampiero Girolomoni
Aug 1, 2020·The American Journal of Dermatopathology·Yumeng M LiFabrizio Galimberti
Jan 16, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Francesco BellinatoGiampiero Girolomoni
May 15, 2021·The American Journal of Dermatopathology·Elizabeth CookGretchen M Roth

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