Clinico-pathological study of cytomegalovirus (CMV) in AIDS autopsies: under-recognition of CMV pneumonitis and CMV adrenalitis

Australian and New Zealand Journal of Medicine
G J DoreJ A Duflou

Abstract

Cytomegalovirus (CMV) is a common cause of morbidity in human immunodeficiency virus (HIV) infected patients, predominantly when severe immunosuppression has occurred. Although CMV infection of the retina and gastrointestinal tract is well recognised as causing substantial morbidity, the significance of infection at other sites, in particular the lungs and adrenal glands is unclear. To assess the extent of CMV infection in postmortem examinations performed on HIV-infected patients. To estimate the degree of concordance between clinical and postmortem findings and the effect of prior diagnosis and/or treatment of CMV infection. The postmortem examination findings and clinical records of 25 consecutive HIV-infected patients who underwent a complete autopsy were examined. CMV infection was demonstrated in 19 patients (76%) at postmortem examination, with the most common sites of infection being the adrenal glands (56%) and lungs (44%). Concordance between clinical diagnosis of CMV infection and postmortem findings was low with only five of 19 patients (26%) having an antemortem diagnosis. No patient with CMV infection of the lungs or adrenal glands had a clinical diagnosis made, despite four patients having florid CMV pneumonitis ...Continue Reading

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Citations

Apr 1, 1997·Endocrine Pathology·Arturo Angeles-AngelesPeter Angritt
Mar 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicolas DurierAnchalee Avihingsanon
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R P Baughman
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·C WeyerS Prösch
Jul 20, 2011·Rare Tumors·Roy PhitayakornScott Wilhelm
Feb 18, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·William F Paolo, Joshua D Nosanchuk
Apr 30, 2003·Pharmacogenomics·Giuseppe BianchiFerrari Patrizia

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