Clinico-radiographic evaluation of 1% alendronate gel as an adjunct and smart blood derivative platelet rich fibrin in grade II furcation defects

Journal of Periodontology
Ishita WanikarAbhay P Kolte

Abstract

The treatment of molar furcation involvement is unpredictable due to the complex anatomy and poor access for instrumentation. Previous studies have reported successful regeneration with endogenous regenerative material such as platelet rich fibrin (PRF) and bisphosphonates as alendronate (ALN). Hence, the present study was aimed to evaluate clinically and radiographically the efficacy of 1% ALN gel in combination with PRF (PRF+ALN) and PRF alone in the treatment of grade II furcation defects. A split mouth study with 40 bilateral furcation defects was randomly divided into PRF group and PRF+ALN group. Bone defect volume was the primary outcome evaluated at the end of 6 months with CBCT while the secondary outcomes being changes in clinical parameters including Probing pocket depth (PPD), Clinical attachment level (CAL) and Horizontal probing depth (HPD) recorded at baseline, 3 and 6 months. The mean reduction in PPD, CAL and HPD was 1.85 ± 0.59 mm, 1.9 ± 0.64 mm and 1.7 ± 0.73 mm respectively for PRF group and 2.85 ± 0.88 mm, 3.05 ± 0.98 mm and 2.3 ± 0.73 mm respectively for PRF+ ALN group (p < 0.05). At the end of 6 months, mean reduction in bone defect volume for PRF and PRF+ ALN group was 8.65 ± 3.84 mm3 and 11.98 ± 4.13 mm3...Continue Reading

References

Jan 1, 1974·Journal of Periodontal Research. Supplement·T O'Leary
Apr 1, 1980·Journal of Clinical Periodontology·J Waerhaug
Jun 1, 1997·Periodontology 2000·R C Page, K S Kornman
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS
Mar 30, 2004·Biomaterials·Gun-Il ImArun S Shanbhag
Oct 11, 2005·Journal of Clinical Periodontology·G FicarraG Pini Prato
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Joseph ChoukrounDavid M Dohan
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Joseph ChoukrounDavid M Dohan
Jun 30, 2006·Journal of Periodontology·Kelly A MischDavid P Sarment
Nov 1, 2006·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Vera de Fátima Padrão CorreiaMárcia Martins Marques
Feb 5, 2008·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·V Sunitha Raja, E Munirathnam Naidu
Apr 9, 2010·Journal of Clinical Periodontology·Clemens WalterNicola U Zitzmann
Sep 21, 2013·Clinical Oral Investigations·X BraunM Frentzen
Jul 6, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Vivek GuptaRajesh Jhingran
Oct 21, 2015·Advanced Drug Delivery Reviews·Lisa E ColeRyan K Roeder
Jun 9, 2016·The Journal of Oral Implantology·Shriparna BiswasGregori M Kurtzman
Mar 17, 2017·Journal of Indian Society of Periodontology·Natasha PajnigaraVrushali Lathiya

❮ Previous
Next ❯

Citations

Dec 21, 2019·Journal of Dental Research, Dental Clinics, Dental Prospects·Prerna Y ShirkePranjali V Bawanakar
Mar 20, 2019·International Journal of Molecular Sciences·Sourav PandaMassimo Del Fabbro
Sep 5, 2021·The Journal of Evidence-based Dental Practice·Kumar KcManash Shrestha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.