Clinicopathologic analysis of a large series of microinvasive breast cancers

The Breast Journal
Tamera J LillemoeJoseph W Leach

Abstract

Clinical management of microinvasive breast cancer (Tmic) remains controversial. Although metastases are infrequent in Tmic carcinoma patients, surgical treatment typically includes lymph node sampling. The objective of this study was to determine the rate and predictors of lymph node metastases, recurrence, and survival in a large series of Tmic breast carcinomas. Consecutive cases of Tmic were identified within our health care system from 2001 to 2015. We reviewed results of lymph node sampling and other pathologic factors including hormone receptor/HER2 status, associated in situ tumor size/grade, margin status, number of invasive foci, surgical/adjuvant therapies, and recurrence/survival outcomes. In this cohort, 294 Tmic cases were identified with mean follow-up of 4.6 years. Of 260 patients who underwent axillary staging, lymph node metastases were identified in 1.5% (all of which were ductal type). All Tmic cases with positive lymph node metastases had associated DCIS with size > 5 cm (5.3-8.5 cm) compared to a median DCIS tumor size of 2.5 cm (0.2-19.0 cm) for the entire cohort. No lymph node metastases were seen with microinvasive lobular carcinoma. During the follow-up period, there were no regional/distant recurrence...Continue Reading

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Citations

May 21, 2020·Annals of Surgical Oncology·Betty FanTed A James
Mar 17, 2019·Breast Cancer Research and Treatment·Emil Villiam Holm-RasmussenTove Filtenborg Tvedskov
Nov 13, 2020·The Journal of International Medical Research·Jie ZhengTao Zhou
Apr 6, 2021·Surgical Oncology·Byung ChoiEkambaram Babu

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