Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas

The American Journal of Surgical Pathology
Hind NassarDaniel W Visscher

Abstract

Solid papillary carcinomas (SPCs) are uncommon tumors composed of circumscribed large cellular nodules separated by bands of dense fibrosis. The aim of this study was to further elucidate the characteristics of SPC, the types and significance of invasive carcinomas associated with these tumors, and the long-term clinical outcome. Fifty-eight SPCs were analyzed (mean follow-up, 9.4 years). Cases were divided into three groups: 1) SPC only (32.7%), 2) SPC with extravasated mucin (8.6%), and 3) SPC with invasive components (58.7%) consisting of neuroendocrine-like (29.5%), colloid (23.5%), ductal not otherwise specified (14.5%), lobular (3%), tubular (3%), or mixed (26.5%). The mean age was 72 years. All were estrogen receptor positive and 86% were histologic grade 1. The total size of the tumor measured 0.3 to 15 cm. In the group with invasive carcinoma, the size of invasion was 0.1 to 4 cm. Axillary nodes were involved in 13% of the cases (6 of 46); all of these had an invasive component in the primary tumor. Local recurrence was seen in 5 patients, all from the group with invasive carcinoma. Overall, 11.7% died of their tumor, 1 to 4 years after diagnosis (mean, 2.3 years); none of them belongs to the group of noninvasive SPC. ...Continue Reading

References

Nov 1, 1980·Histopathology·C CapellaJ G Azzopardi
Mar 1, 1997·Ultrastructural Pathology·G R DickersinF C Koerner
Mar 27, 2002·The American Journal of Surgical Pathology·Sandra J Shin, Paul Peter Rosen
Oct 18, 2002·American Journal of Surgery·Carmen C SolorzanoGildy Babiera

❮ Previous
Next ❯

Citations

Mar 27, 2010·Medical Molecular Morphology·Naoto KurodaGang-Hong Lee
Oct 13, 2006·Breast Cancer Research and Treatment·Gary M K TseHumairah S Cheung
Jun 5, 2010·Breast Cancer Research and Treatment·Sumanta Kumar PalGeorge Somlo
May 29, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takuya MoriyaMika Watanabe
Jul 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Britta WeigeltJorge S Reis-Filho
Jun 23, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Omar HameedJohn D Pfeifer
Jul 16, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R YerushalmiK A Gelmon
Jun 26, 2007·Pathology International·Yoshiro OtsukiHiroshi Kobayashi
Apr 25, 2012·Pathology International·Takashi InozumeShinji Shimada
Aug 12, 2010·Indian Journal of Pathology & Microbiology·Sandhya SundaramS Rajendiran
Jul 12, 2013·Case Reports in Surgery·Noriko YoshimuraWataru Takiyama
Oct 2, 2012·Archives of Pathology & Laboratory Medicine·Jinous Saremian, Marilin Rosa
Mar 29, 2016·The Breast : Official Journal of the European Society of Mastology·Shuangping GuoZhe Wang
Jun 1, 2009·Surgical Pathology Clinics·Anna Marie Mulligan
Aug 24, 2007·The Breast : Official Journal of the European Society of Mastology·Giuseppe Viale
Jun 19, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·A BhatiaY Kumar
Jan 4, 2008·Histopathology·L C Collins, S J Schnitt
Oct 12, 2007·Histopathology·M M NicolasM Z Gilcrease
Oct 26, 2011·The Journal of Pathology·Raphaëlle DuprezJorge S Reis-Filho
Dec 30, 2014·Pathology International·Xiaoyan Cui, Shi Wei
Jul 29, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J FekiM Frikha
Jun 27, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna Melissa SchlitterVolkan Adsay
Apr 5, 2014·BioMed Research International·David L WachterAbbas Agaimy
Jul 1, 2016·Archives of Pathology & Laboratory Medicine·Shi Wei
Jul 30, 2016·Archives of Pathology & Laboratory Medicine·Mehdi AgoumiMalcolm M Hayes
Oct 4, 2016·Clinical Breast Cancer·Yihong WangEvgeny Yakirevich
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Julie M Jorns
Jun 25, 2008·International Journal of Surgical Pathology·Alka BhatiaYashwant Kumar
Mar 28, 2018·International Journal of Surgical Pathology·Hideharu DomotoKiyoshi Mukai
Jan 25, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Dokyung KimJa Seung Koo
Jun 21, 2007·Diagnostic Cytopathology·Makoto YamadaHiroshi Kobayashi
May 2, 2007·Advances in Anatomic Pathology·Anna Marie Mulligan, Frances P O'Malley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.