PMID: 9445183Jan 28, 1998Paper

Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors

Cancer
S SenbaT Tsukamoto

Abstract

DNA replication errors (RERs) are closely associated with hereditary nonpolyposis colorectal carcinoma (HNPCC). Recently, alterations in DNA mismatch repair genes, including hMSH2, hMLH1, and hPMS2, have been implicated in the pathogenesis of HNPCC: Several studies have demonstrated RER in 13-17% of nonfamilial colorectal carcinomas. It is unclear, however, as to whether or not these RER positive nonfamilial colorectal carcinomas are incomplete forms of HNPCC or are caused by incidental alterations of DNA mismatch repair genes. Consequently, the authors studied the characteristics of RER positive nonfamilial colorectal carcinomas, placing particular emphasis on hMSH2 and hMLH1 gene mutations. Fresh or frozen samples of 103 nonfamilial colorectal carcinomas were examined for RERs using the polymerase chain reaction (PCR) and specific microsatellite primers. The authors also identified mutations of the hMSH2 and hMLH1 genes in RER positive samples by a PCR single strand conformational polymorphism analysis followed by direct nucleotide sequencing. The incidence of RER was 15.7% (17/103) in nonfamilial colorectal carcinomas, and only 1 case, which was found in the ascending colon, showed a somatic mutation at exon 12 in the hMSH2 ...Continue Reading

Citations

Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J R JassB A Leggett
Dec 29, 2000·Journal of Clinical Pathology·K ShitohH Nagai
Oct 23, 2002·Alimentary Pharmacology & Therapeutics·J D Trimbath, F M Giardiello
Jul 24, 1998·Histopathology·J R Jass
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E CapozziA Viel
Oct 13, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R ZhangC-X Li
Aug 31, 2002·Genes, Chromosomes & Cancer·Taiji FurukawaToshihiko Tsukamoto
May 4, 2002·Journal of Gastroenterology and Hepatology·Jereny R JassBarbara A Leggett
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·J W HoI S Luk
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Yoshihiro KazamaHirokazu Nagawa

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