Clinicopathologic characteristics and long-term prognosis of scirrhous hepatocellular carcinoma.

Digestive Diseases and Sciences
Jin Hee LeeCheol Keun Park

Abstract

Clinicopathologic features and long-term outcomes in patients with scirrhous hepatocellular carcinoma (S-HCC) are not fully defined. We compared data of 37 patients with S-HCC and 604 with usual HCC (U-HCC) undergoing surgery. The S-HCC group showed less HBV infection (78.4 vs. 92.0%, P = 0.02), low serum AFP level (2320 ± 6356 vs. 3297 ± 18690 ng/ml, P < 0.0001), less delayed washout during CT (72.7 vs. 90.7%, P = 0.004), and low usefulness of clinical diagnostic criteria (32.4 vs. 57.5%, P = 0.003), compared to the U-HCC group. More portal vein invasion (18.9 vs. 4.1%, P = 0.03) and less liver cirrhosis (35.1 vs. 65.1%, P = 0.001) and fibrous capsule (40.5 vs. 81.6%, P < 0.001) were noted in the S-HCC group than the U-HCC group. Long-term survival rates were similar between the S-HCC and U-HCC groups, even with subgroup analysis according to Child-Pugh score and modified UICC stage. The S-HCC group showed distinct patient and tumor characteristics but similar long-term outcome.

References

Mar 1, 1992·Journal of Computer Assisted Tomography·J YoshikawaT Takashima
Mar 1, 1992·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·J YoshidaY Muramatsu
Jan 1, 1993·Abdominal Imaging·Y YamashitaM Takahashi
Aug 10, 2000·Abdominal Imaging·C VallsJ Figueras
Nov 27, 2002·Journal of Magnetic Resonance Imaging : JMRI·Satoshi GoshimaHiroaki Hoshi
Jan 22, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Iwao IkaiYoshio Yamaoka
Aug 17, 2006·Journal of Gastroenterology and Hepatology·Mina KurogiMasamichi Kojiro
Jan 5, 2007·Abdominal Imaging·Seong Hyun KimCheol Keun Park
May 14, 2009·World Journal of Gastroenterology : WJG·Soo-Ryang KimYoshitake Hayashi
Oct 1, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Bryan L CoppleJeon-Ok Moon
Dec 24, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Juliane S Troeger, Robert F Schwabe

❮ Previous
Next ❯

Citations

Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Zongming Eric Chen, Fan Lin
Dec 31, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Junki MaeharaMichiie Sakamoto
Jan 20, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun JiangBarbara A Centeno
Apr 24, 2019·World Journal of Gastroenterology : WJG·Tony El JabbourHwajeong Lee
Jun 28, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ayesha FarooqTimothy M Pawlik
Feb 6, 2021·Hepatology International·Shang-Chin HuangJia-Horng Kao
Apr 3, 2014·Topics in Magnetic Resonance Imaging : TMRI·Daniel C Barr, Hero K Hussain
Oct 6, 2020·Clinics in Liver Disease·Monika Vyas, Xuchen Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.