Clinicopathologic characteristics and outcomes of renal thrombotic microangiopathy in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis

Clinical Journal of the American Society of Nephrology : CJASN
Su-Fang ChenMin Chen

Abstract

Thrombotic microangiopathy (TMA) in ANCA-associated vasculitis (AAV) has been mainly reported in isolated case reports. The aim of this study was to analyze clinical and pathologic characteristics and prognosis of patients with renal TMA in ANCA-associated GN in a large cohort of Chinese patients. Clinical and renal histopathologic data of 220 patients with biopsy-proven ANCA-associated GN from 1996 to 2013 were retrospectively analyzed. Patients were followed up for a median period of 32 (interquartile range [IQR], 12-65) months, and outcomes of patients were analyzed. Among the 220 patients with ANCA-associated GN, 30 were identified having concomitant renal TMA by pathologic evaluation. Compared with the non-TMA group, patients with renal TMA presented with more severe renal injury, as evidenced clinically by a higher level of serum creatinine at diagnosis (5.0 [IQR, 3.5-9.0] versus 3.2 [IQR, 1.7-6.8] mg/dl; P=0.02) and pathologically by a higher percentage of cellular crescents (15.0% [IQR, 6.9%-34.9%] versus 6.9% [IQR, 0%-21.1%]; P=0.04) and more severe interstitial infiltration (2 [IQR, 2-2] versus 2 [IQR, 1-2]; P=0.03) in renal biopsies. Furthermore, multivariate analysis showed that renal TMA was independently associate...Continue Reading

References

Aug 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J HirschA A Trillo
Oct 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I M BajemaJ A Bruijn
Jul 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I StefanidisH G Sieberth
Jan 12, 2002·Kidney International·Herbert A HauerUNKNOWN European Vasculitis Study Group (EUVAS)
Oct 10, 2002·Kidney International·Herbert A HauerUNKNOWN European Vasculitis Study Group (EUVAS)
Mar 13, 2003·Kidney International·J Charles Jennette
Nov 20, 2003·Seminars in Arthritis and Rheumatism·Andy AbrilMarc D Cohen
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Dec 17, 2008·Journal of the American Society of Nephrology : JASN·Adrian SchreiberRalph Kettritz
May 19, 2009·Nature Medicine·Kai KessenbrockDieter E Jenne
Oct 23, 2009·The New England Journal of Medicine·Marina Noris, Giuseppe Remuzzi
Jun 12, 2010·Current Opinion in Nephrology and Hypertension·Peter F ZipfelChristine Skerka
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Annelies E BerdenIngeborg M Bajema
Apr 19, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Varun AgrawalGregory L Braden
Nov 18, 2011·Current Opinion in Rheumatology·Mirjan M van Timmeren, Peter Heeringa
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Jun 7, 2013·The New England Journal of Medicine·C M LegendreC Loirat
Jun 8, 2013·European Journal of Internal Medicine·Seppo Meri
Nov 2, 2013·Journal of the American Society of Nephrology : JASN·Hong XiaoJ Charles Jennette
Dec 24, 2013·Seminars in Arthritis and Rheumatism·Michael H Rosove
Jan 5, 2014·Journal of the American Society of Nephrology : JASN·Daigo NakazawaAkihiro Ishizu
Aug 15, 2014·The New England Journal of Medicine·James N George, Carla M Nester

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Citations

Mar 21, 2017·Nature Reviews. Nephrology·Min ChenMing-Hui Zhao
Aug 14, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alvise BertiUlrich Specks
Oct 2, 2019·Indian Journal of Nephrology·Jasmine SethiKrishan Lal Gupta
May 30, 2019·American Journal of Physiology. Renal Physiology·Ayesha GhayurPeter J Margetts

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