Clinicopathologic characteristics and subsequent pregnancy outcome in 139 complete hydatidiform moles

European Journal of Obstetrics, Gynecology, and Reproductive Biology
L-C HornJ Einenkel

Abstract

The most common form of gestational trophoblastic disease is the complete hydatidiform mole (CHM). The study reports our experience of clinicopathologic characteristics and subsequent pregnancy outcome of patients with CHM. One hundred fifty-one subsequent cases with initial diagnosis of CHM were re-evaluated histopathologically. Clinical characteristics, the need for chemotherapy and subsequent pregnancy outcome were evaluated. Twelve out of 151 cases were re-evaluated as hydropic abortion, as partial hydatidiform moles or were insufficient for morphologic examination and therefore excluded from further analysis. The leading clinical symptoms of the remaining 139 cases were irregular vaginal bleeding (67%) and uterine enlargement (41%). Twenty-six patients (19%) required chemotherapy because of gestational trophoblastic neoplasia (GTN; low-risk: 23 out of 26). All patients were cured successfully. The subsequent pregnancy rate was 15% (21/139). Five patients suffered from abortions, 12 women delivered a healthy offspring. Four women presented with recurrent CHM with a spontaneous normalization of HCG levels after D&C. The clinical and morphologic diagnosis of CHM is a challenge, and diagnosis as well as treatment should be mul...Continue Reading

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Citations

Dec 13, 2012·European Journal of Human Genetics : EJHG·Ramesh ReddyRima Slim
Aug 22, 2013·Molecular Human Reproduction·L AndreasenL Sunde
Jul 16, 2008·Southern Medical Journal·Robert MurphyDebra Houry
Apr 4, 2012·Cancer Genetics·Lori Hoffner, Urvashi Surti
Mar 10, 2016·European Journal of Human Genetics : EJHG·Ramesh ReddyRima Slim
May 20, 2015·Reproductive Biomedicine Online·Elie AkouryRima Slim
May 9, 2018·Fetal and Pediatric Pathology·M Halit PinarRobert Silver
Feb 22, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ngoc Minh Phuong NguyenRima Slim
Oct 26, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hirokazu UsuiMakio Shozu
Mar 8, 2020·International Journal of Clinical Oncology·Eiko YamamotoFumitaka Kikkawa
Feb 8, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Vito Andrea CapozziRoberto Berretta

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