Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome: A French Multicenter Study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Léa RossiAnne-Sophie Bats

Abstract

Limited data exist on Lynch syndrome (LS)-related endometrial cancer (EC) features. Amsterdam criteria II, commonly used, have poor sensitivity for detection of LS, which is underdiagnosed. The aim of this study was to describe the clinical and pathological features of LS-related EC among mutation-proven patients. We conducted a retrospective study from 1977 to 2013 in 5 hospitals. The inclusion criteria were patients who had a primary EC associated to LS proven by a germline mutation. We analyzed the clinical data and the pathology of the tumors. The patient management and the survival data were also collected. Forty-nine patients (15 MLH1, 20 MSH2, 13 MSH6, 1 PMS2) were included. The mean age at diagnosis was 49.7 (SD, 10.5) years. The median body mass index was 22.6 kg/m. In 81.4% of cases, EC was the first cancer of the LS spectrum to occur. Endometrioid adenocarcinoma accounted for 89.2% of the EC, the lower uterine segment was involved in 25% of cases, and a synchronous ovarian cancer was present in 21.6% of patients. The tumors were grade 3 in 19.3% of cases and FIGO (International Federation of Gynecology and Obstetrics) stage I in 66.6% of cases. With a median follow-up of 58 months, 3 patients with conservative manage...Continue Reading

References

Jun 1, 1989·Gynecologic Oncology·R F EisnerJ S Berek
Jun 17, 1998·International Journal of Cancer. Journal International Du Cancer·F ParazziniS Francheschi
Oct 18, 2002·International Journal of Cancer. Journal International Du Cancer·Dominique E S BoksHans F A Vasen
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Päivi Peltomäki
Aug 9, 2005·Lancet·Frederic AmantIgnace Vergote
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Destin BlackJeff Boyd
Apr 12, 2007·British Journal of Cancer·L A BrintonM Garcia-Closas
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Israel ZighelboimDavid G Mutch
Oct 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen H LuRussell R Broaddus
Mar 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael D WalshAndreas Obermair
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shannon N WestinRussell R Broaddus
Jun 7, 2011·JAMA : the Journal of the American Medical Association·Valérie BonadonaUNKNOWN French Cancer Genetics Network
Nov 22, 2011·Gynecologic Oncology·H M J WernerUNKNOWN MoMaTEC study group
Feb 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aung Ko WinMark A Jenkins
Mar 21, 2012·Advances in Cancer Research·Chrystelle ColasRichard Hamelin
Oct 18, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jeong-Yeol ParkJoo-Hyun Nam
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph EngelHans F A Vasen
May 17, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ernest K AmankwahLinda S Cook
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Veronica Wendy SetiawanPamela L Horn-Ross
Feb 5, 2014·International Journal of Cancer. Journal International Du Cancer·Verena SteinkeUNKNOWN German HNPCC Consortium
Sep 18, 2014·The American Journal of Surgical Pathology·Anne M MillsTeri A Longacre
Feb 20, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yusuke KobayashiDaisuke Aoki
May 15, 2015·European Journal of Epidemiology·Anika HüsingRudolf Kaaks
Jun 24, 2015·Journal of Medical Genetics·Elaine F HarknessD Gareth Evans
Jul 18, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alexandros RodolakisDominik Denschlag

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Citations

Mar 29, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anni NiskakoskiPäivi Peltomäki
Oct 18, 2018·Annual Review of Pathology·Daphne W Bell, Lora Hedrick Ellenson
Feb 18, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFrancesco Raspagliesi
May 6, 2019·International Journal of Cancer. Journal International Du Cancer·Wenjuan TianHuaying Wang
Jul 30, 2019·Journal of Surgical Oncology·Alexandra S Bercow, Eric L Eisenhauer
Jun 25, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Megan A Mullins, Michele L Cote
Nov 30, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFrancesco Raspagliesi
Sep 30, 2020·Journal of Clinical Medicine·Piotr K ZakrzewskiWanda M Krajewska
Aug 26, 2019·Journal of Visceral Surgery·B MenahemC Sabbagh
Dec 18, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lea A MoukarzelBritta Weigelt
Aug 17, 2021·International Journal of Cancer. Journal International Du Cancer·Shuangshuang ZhaoYingmei Wang

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