Clinicopathologic correlation and outcome of C1q nephropathy

Clinical Journal of the American Society of Nephrology : CJASN
Satoshi HisanoHiroshi Iwasaki

Abstract

The number of patients with C1q nephropathy (C1qN) in previous reports is small and the duration of follow-up is short. Our study describes the clinicopathologic correlation and clinical outcome through the mean follow-up period of 7.2 yr in 61 patients. Sixty-one patients, 1 to 67 yr of age, with C1qN were enrolled in this study. According to presentation at onset, patients were divided into two groups: asymptomatic urinary abnormalities (asymptomatic) (n = 36) and nephrotic syndrome (NS) (n = 25). Light microscopy showed minimal change disease (MCD) in 46 patients (75%), mesangial proliferative glomerulonephritis in 7 (12%), and focal segmental glomerulosclerosis (FSGS) in 8 (13%). The prevalence of MCD was higher in the NS group than in the asymptomatic group. Nine patients in the asymptomatic group and all patients in the NS group were treated with prednisolone and/or cyclosporine. Normal urinalysis was found in 10 patients in asymptomatic group and 8 in NS group during the follow-up. Thirteen patients in the NS group were frequent relapsers at the latest follow-up. Three patients with FSGS developed chronic renal failure 8 to 15 yr after the diagnosis. C1q deposits disappeared in 3 of 8 patients receiving repeat biopsy, an...Continue Reading

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Citations

May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samar M SaidSamih H Nasr
Nov 28, 2013·Nephro-urology Monthly·Pavan Malleshappa, Mahesha Vankalakunti
Dec 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vindya N GunasekaraKjell Tullus
Apr 18, 2009·Clinical and Experimental Nephrology·Akiko MiiYuh Fukuda
Nov 26, 2010·Clinical and Experimental Nephrology·Aditi SinhaStanley C Jordan
Jul 24, 2012·Clinical and Experimental Nephrology·Takashi TakeiKosaku Nitta
Dec 8, 2015·Analytical Cellular Pathology (Amsterdam)·Joe DevasahayamUnni Pillai
Jan 18, 2019·The Tohoku Journal of Experimental Medicine·Yasushi Chiba, Chiyoko N Inoue
Aug 1, 2009·NDT Plus·Mordi MuorahPatrick J O'Donnell

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