Clinicopathologic correlation of submacular membranectomy with retention of good vision in a patient with age-related macular degeneration

Archives of Ophthalmology
R H RosaW R Green

Abstract

We present the clinicopathologic features of the eye of a patient with age-related macular degeneration who underwent submacular membranectomy and had retention of good visual acuity for almost 4 years despite recurrent choroidal neovascularization treated with krypton laser photocoagulation and mild expansion of the laser lesion with time. Histopathologic study of the surgically removed membrane from the right eye disclosed a thin fibrovascular membrane lined by retinal pigment epithelium on one surface. Microscopic examination of the right eye obtained post mortem disclosed a 2.75-mm (horizontal) x 2.1-mm (vertical) retinal pigment epithelium defect with overlying photoreceptor cell atrophy centered on the temporal parafoveal area, and a 0.6 x 0.1-mm subretinal pigment epithelium fibrovascular membrane with an area of retinal pigment epithelial hyperplasia and vascularization from the retina 0.4 mm temporal to the fovea. Basal laminar deposit was present in the region of the fovea and nasal parafoveal area.

Citations

Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Jan 20, 1999·The British Journal of Ophthalmology·C ShiragamiN Matsuo
Oct 9, 2007·Progress in Retinal and Eye Research·Lyndon da CruzPete Coffey
Jan 27, 2005·Experimental Eye Research·Vamsi K GullapalliMarco A Zarbin
Jun 8, 2004·Clinical & Experimental Ophthalmology·Sachiko KuroiwaNagahisa Yoshimura
Jun 1, 1997·Indian Journal of Ophthalmology·T Das
Mar 14, 2003·Experimental Eye Research·Debra S LeonardMarco A Zarbin

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