Clinicopathologic evaluation of MYC expression in primary mediastinal (thymic) large B-cell lymphoma

American Journal of Clinical Pathology
K David LiMohamed Salama

Abstract

Based on previous molecular studies, a small fraction of primary mediastinal (thymic) large B-cell lymphoma (PMBL) demonstrates MYC alterations. However, no studies have evaluated MYC protein expression by immunohistochemistry (IHC) with follow-up fluorescence in situ hybridization (FISH) analysis. We aim to evaluate the clinicopathologic importance of MYC IHC expression in PMBL. Three pathologists independently evaluated MYC IHC expression in 32 cases of PMBL for percent tumor positivity and nuclear intensity. FISH analysis for MYC rearrangement was performed on cases with high MYC IHC expression. Clinical data including treatment, follow-up, and outcome were also reviewed in a subset of cases. Variable MYC protein expression by IHC was detected in 30 (94%) of 32 cases of PMBL. One-third of the positive cases (10/30) showed high MYC IHC expression of at least 30% nuclear positivity. FISH analyses for MYC rearrangement on these 10 cases were negative. Review of clinical data on a subset of cases with high and low MYC IHC expression showed no differences in clinical outcome. MYC protein expression by IHC is present in most PMBLs. Increased MYC protein expression can be seen in one-third of the cases; however, it does not correla...Continue Reading

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Citations

Apr 29, 2016·American Journal of Clinical Pathology·Germán Campuzano-ZuluagaJennifer R Chapman
Jun 9, 2017·Diagnostic Cytopathology·Charles D SturgisLiron Pantanowitz
Sep 14, 2018·The American Journal of Surgical Pathology·Bo-Jung ChenLeticia Quintanilla-Martinez
Jun 28, 2021·Seminars in Diagnostic Pathology·Xiaoqiong WangAndres E Quesada

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