Clinicopathologic evaluation of the Mueller muscle in thyroid-associated orbitopathy

Ophthalmic Plastic and Reconstructive Surgery
Kimberly P CockerhamScott R Graner

Abstract

To study the histopathologic features of the Mueller muscle in chronic eyelid retraction caused by thyroid-associated orbitopathy. To investigate if the degree of eyelid retraction correlates with any histopathologic finding. A prospective case series of 23 consecutive patients with thyroid-associated orbitopathy was studied. Specimens were obtained during a standard muellerectomy. Formalin-preserved specimens were studied with the use of hematoxylin-eosin, periodic acid-Schiff, Masson trichrome, and Giemsa stains. Immunostaining against leukocyte common antigen, L26, CD3, and KP-1 was performed. Three control specimens were also evaluated in a similar fashion. Fresh tissue was placed in cold glutaraldehyde overnight, postfixed, dehydrated, and infiltrated with epoxy resin. Silver (70 nm) sections were cut and stained with uranyl acetate and lead citrate for electron microscopic examination. On light microscopy, fibrosis and mast cell infiltration was present in all 23 specimens. Fat infiltration was noted in 16 of 23 specimens and did not correlate with increasing age of the patient. Interstitial edema and lymphocytic infiltration were not observed. On immunohistochemistry, leukocyte common antigen was positive, confirming the...Continue Reading

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Citations

Sep 12, 2014·International Journal of Trichology·Niloufar TorkamaniRodney D Sinclair
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Jun 6, 2018·Ophthalmic Plastic and Reconstructive Surgery·Jonathan J Dutton
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Mar 10, 2011·Ophthalmic Plastic and Reconstructive Surgery·Valentín Huerva

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