Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers

American Journal of Clinical Pathology
Britta HalvarssonMef Nilbert

Abstract

Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers.

References

Sep 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J R JassM R Lane
Apr 10, 1997·Nature·C LengauerB Vogelstein
May 21, 1998·The New England Journal of Medicine·L A AaltonenA de la Chapelle
Jan 1, 1999·Nature·C LengauerB Vogelstein
Dec 14, 1999·The American Journal of Pathology·A LoukolaL A Aaltonen
Feb 13, 2001·The American Journal of Pathology·J AlexanderS R Hamilton
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J R JassB A Leggett
Oct 25, 2003·The American Journal of Surgical Pathology·Cheryl L Wright, Ian D Stewart
Dec 4, 2003·Virchows Archiv : an International Journal of Pathology·Britta HalvarssonMef Nilbert
Mar 16, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarThomas C Smyrk
Sep 3, 2004·Journal of Medical Genetics·E DomingoS Schwartz
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PopatR S Houlston
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Piero BenattiGiovanni Lanza
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni LanzaLuigi Cavazzini
Sep 9, 2006·Science·Tobias SjöblomVictor E Velculescu
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Laura Renkonen-SinisaloHeikki J Järvinen
Oct 13, 2007·Science·Laura D WoodBert Vogelstein

❮ Previous
Next ❯

Citations

Jun 28, 2014·Diagnostic Pathology·Patrick JoostMef Nilbert
Oct 3, 2008·The American Journal of Surgical Pathology·Joel K GreensonStephen B Gruber
Dec 23, 2011·Annals of Surgical Oncology·Teppei MorikawaShuji Ogino
Jan 15, 2011·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Jin PengLi Shi-rong
Jul 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xavier BessaMontserrat Andreu
Dec 19, 2018·International Journal of Cancer. Journal International Du Cancer·Inna ZaimenkoJan Lisec
Jan 22, 2009·The American Journal of Dermatopathology·Dmitry V KazakovMichal Michal
Jun 27, 2014·Journal of Biomedical Optics·Lianhuang LiJianxin Chen
Apr 16, 2011·Virchows Archiv : an International Journal of Pathology·Jeong Mo BaeGyeong Hoon Kang
Nov 9, 2020·Human Pathology·Kyriakos ChatzopoulosGeorge Fountzilas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.