Clinicopathologic features and human papillomavirus dna prevalence of warty and squamous cell carcinoma of the penis

The American Journal of Surgical Pathology
A L BezerraL L Villa

Abstract

Squamous cell carcinoma (SCC) accounts for 95% of penile malignant neoplasms. A subtype of SCC, named warty carcinoma (WC), is a morphologically distinct verruciform tumor with features of human papillomavirus (HPV)-related lesions. Descriptions of the behavior and histologic features of this tumor are scarce in the literature. The aim of this report is to analyze the clinicopathologic features and HPV deoxyribonucleic acid status in 60 SCCs and 11 WCs. The mean patient age was 46.5 +/- 15.9 years for WC and 52.6 +/- 12.4 years for SCC. No significant differences in age (p = 0.154) and clinical staging (T, p = 0.649; N, p = 0.497) between the two groups of tumors were found. When compared with SCCs, WCs exhibited less lymphatic embolization (p = 0.001), nodal metastasis (p = 0.019), and corpora cavernosa and corpus spongiosum infiltration (p = 0.040). Lymph node metastases were found in 34 of 60 SCC patients (56.7%) and in two of 11 WC patients (18.2%). No patients with WC tumors died of the disease compared with 19 of 60 (5-year specific survival, 66.0%) in the SCC group (p = 0.032). HPV deoxyribonucleic acid was more likely to be associated with WC (five of 11, 45.5%) than SCC (16 of 60, 26.7%), although significance was not ...Continue Reading

References

Feb 1, 1992·The Journal of Urology·F H SarkarJ D Crissman
Aug 1, 1991·American Journal of Obstetrics and Gynecology·W A AndersenC P Crum
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·D J McCanceR Doll
Jun 15, 1986·International Journal of Cancer. Journal International Du Cancer·L L Villa, A Lopes
May 1, 1973·Urology·D E JohnsonA G Ayala
Jan 1, 1995·Gynecologic Oncology·R H Kaufman
Feb 1, 1997·Current Opinion in Obstetrics & Gynecology·C P CrumG L Mutter
Jun 13, 1998·Molecular Pathology : MP·A P Pinto, L L Villa

❮ Previous
Next ❯

Citations

Apr 20, 2006·Der Urologe. Ausg. A·E PreisG Jakse
Jan 5, 2007·Der Urologe. Ausg. A·E Preis, G Jakse
Aug 5, 2003·Sexually Transmitted Diseases·Eric M van der SnoekWillem I van der Meijden
Oct 14, 2011·Preventive Medicine·Gabriella M Anic, Anna R Giuliano
Aug 19, 2010·Urology·Alcides ChauxAntonio L Cubilla
Jun 16, 2009·The Journal of Urology·Gustavo Cardoso GuimarãesAntonio L Cubilla
Apr 2, 2009·International Journal of Experimental Pathology·Dorrit KrustrupMorten Frisch
Nov 5, 2008·Cancer·Brenda Y HernandezJose M Villalon-Gomez
Feb 10, 2006·Journal of Cutaneous Pathology·David S CassarinoRonald J Barr
Dec 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J J BonerandiUNKNOWN French Dermatology Recommendations Association (aRED)
Jun 9, 2004·European Urology·E SolsonaUNKNOWN European Association of Urology
Sep 5, 2006·Vaccine·D Maxwell Parkin, Freddie Bray
Feb 21, 2006·Journal of the American Academy of Dermatology·Giuseppe MicaliRobert A Schwartz
Nov 19, 2013·Urologic Oncology·Amber FlahertyPhilippe E Spiess
Jul 2, 2016·Virusdisease·Damiano PizzolKajal D Chhaganlal
Sep 10, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcos A ScheinerMaria J Andrada-Serpa
Nov 7, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Luciano A FavoritoSidney Glina
Oct 17, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Paulo Ornellas, Antonio Augusto Ornellas
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
Dec 14, 2011·British Journal of Cancer·D M Parkin
Jun 10, 2014·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Shintaro UraJyoji Haratake
Jan 24, 2020·Current Opinion in Urology·João F da Costa NunesDaher C Chade
Feb 6, 2016·The American Journal of Surgical Pathology·Diego F SanchezAntonio L Cubilla
Aug 27, 2009·Journal of Clinical Pathology·C Miralles-GuriS de Sanjosé
Apr 25, 2006·Journal of Cutaneous Pathology·David S CassarinoRonald J Barr
Jun 17, 2003·Journal of the National Cancer Institute. Monographs·Maura L Gillison, Keerti V Shah
Jun 17, 2003·Journal of the National Cancer Institute. Monographs·Mark Schiffman, Susanne Krüger Kjaer
Jan 28, 2012·Anais Brasileiros De Dermatologia·Fabiana Braga França WanickLucia Maria Soares de Azevedo
Feb 6, 2017·Case Reports in Pathology·Sushma ThapaO P Talwar
May 13, 2021·Journal of Surgical Case Reports·Ilou ParkHee Jeong Lee
May 18, 2021·Clinical Medicine Insights. Case Reports·Bouhani MalekRahal Khaled
Mar 1, 2009·Surgical Pathology Clinics·Matthew J Wasco, Rajal B Shah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.