Clinicopathologic features and outcomes in patients with diffuse sclerosing variant of papillary thyroid carcinoma

World Journal of Surgery
Junko AkaishiKoichi Ito

Abstract

Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients. Excluding patients with microcarcinoma, 5848 patients with PTC underwent initial surgery between 1995 and 2011. Twenty-two patients (0.4 %) were histologically diagnosed with DSV, of whom 20 (91 %) were <45 years old. We compared clinicopathologic characteristics and outcomes between patients with DSV and those with classical PTC <45 years old. Univariate analysis by the Kaplan-Meier method in relation to cause-specific survival (CSS) and disease-free survival (DFS) rates was performed with regard to the following variables: sex; anti-thyroglobulin antibody (TgAb) positivity; presence of distant metastasis; pathological lymph node metastasis; extra-thyroidal invasion; and pathological variant (classical vs. DSV). The 20 patients with DSV <45 years old comprised 18 females and 2 males. Frequencies of TgAb, pN1b, and local recurrence were higher in the DSV group than in the classical PTC group. Ten-year CSS and DFS rates for PTC patients <45 years old were 99.7 and 88.6 % in the classical PTC group and 100 and 60.5 % in the DSV group. CSS rate did not differ between groups, but DFS rate was significantly low...Continue Reading

References

Sep 1, 1990·Acta Pathologica Japonica·Y MizukamiH Kurumaya
May 1, 1991·Clinical Endocrinology·M Gómez-MoralesF Escobar
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·S SchröderH Kastendieck
Dec 1, 1989·The American Journal of Surgical Pathology·M L Carcangiu, S Bianchi
Aug 1, 1989·Pathology, Research and Practice·J SoaresM Sobrinho-Simões
Sep 21, 2002·Journal of Endocrinological Investigation·N KebapciM Kebapci
Jun 12, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S-M ChowW-H Lau
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R H CaplanA W Kisken
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Ji Young LeeJae Hoon Chung
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Ja Seung KooCheong Soo Park
Sep 22, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ja Seung KooSoon Won Hong
Feb 12, 2011·Thyroid : Official Journal of the American Thyroid Association·Concetto RegalbutoVincenzo Pezzino

❮ Previous
Next ❯

Citations

May 4, 2016·Current Opinion in Pediatrics·Andrew J Bauer, Gary L Francis
Jun 29, 2016·Thyroid : Official Journal of the American Thyroid Association·Pasqualino MalandrinoRiccardo Vigneri
Apr 18, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Davide LombardiPiero Nicolai
Jul 31, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Andrew J Bauer
Dec 12, 2018·Pathology International·Kennichi KakudoChan Kwon Jung
Oct 13, 2019·World Journal of Surgery·Claudio SpinelliGabriele Materazzi
Nov 7, 2020·Endocrinology and Metabolism Clinics of North America·Andrew J Bauer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.