PMID: 15244191Jul 13, 2004Paper

Clinicopathologic features, cellular differentiation, PCNA and P53 expressions in gastrointestinal stromal tumors

Hepato-gastroenterology
Bilge Can, Cenk Sökmensüer

Abstract

Gastrointestinal stromal tumors are currently defined, as specific c-kit positive primary mesenchymal tumors of the gastrointestinal tract. Although increasing tumor size and mitotic activity favours aggressive behaviour, no specific histological criteria that enable the prediction of biological behaviour have yet been identified. The purpose of this study is, (1) to determine whether cell differentiation of gastrointestinal stromal tumors could be detected through their expression of various antigens, (2) to correlate their macroscopic and histologic features with cell differentiation, p53 expression, PCNA score and clinical outcome. 65 gastrointestinal stromal tumors were included in this study. All cases were reviewed in terms of clinical presentation and courses. The cell morphology, growth pattern, cellularity, pleomorphism, mucosal invasion, necrosis and mitotic index were evaluated. Tissue sections were immunostained with CD117, CD34, alpha-smooth muscle actin, and S-100 protein. PCNA score and p53 expressions were investigated to determine whether these could be used as prognostic indicator. Clinical outcome was obtained for 42 of the 65 patients. The follow-up time ranged from 1 to 240 months (median: 20 months). The t...Continue Reading

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