Clinicopathologic Features, Diagnosis, and Characterization of the Immune Cell Population in Canine Choroid Plexus Tumors

Frontiers in Veterinary Science
Martha F DaltonD R Rissi

Abstract

The World Health Organization characterizes human choroid plexus tumor (CPT) as papilloma (CPP), atypical CPP (ACPP), and carcinoma (CPC). CPCs can disseminate via cerebrospinal fluid and be mistaken for metastatic carcinoma, creating a diagnostic challenge. Kir7.1 immunohistochemistry (IHC) is a highly reliable tool for diagnostic confirmation of CPTs and their differentiation from metastatic carcinomas in human beings and dogs. This study describes the neuropathology, Kir7.1 staining profile, and the immune cell population within the tumor microenvironment in 11 CPTs in dogs. Archived tissue sections with a diagnosis of CPT were examined and immunolabelled with Kir7.1 for diagnostic confirmation. The number of Ki67-positive neoplastic cells was calculated in 2.4 mm2 (equivalent to 10 FN22/40X fields), and a mean value was generated for each neoplasm. IHC for CD3, CD20, MAC387, and Iba1 was performed for immune cell characterization, and the number of stained cells for each antibody was counted in 2.4 mm2, generating individual cumulative values for each antibody. T-tests with Bonferroni correction evaluated IHC differences between tumor types, and Spearman's rank correlations evaluated relationships among IHC markers. Kir7.1 ...Continue Reading

References

Jul 1, 1991·Journal of Veterinary Internal Medicine·G L HeidnerD E Thrall
Apr 12, 2002·Journal of Comparative Pathology·C CantileM Arispici
Dec 9, 2003·Journal of Veterinary Internal Medicine·Mark T TroxelSheldon A Steinberg
Dec 7, 2005·The American Journal of Surgical Pathology·Martin HasselblattWerner Paulus
Jul 6, 2006·Journal of Comparative Pathology·R KlopfleischJ P Teifke
Sep 6, 2006·Journal of Comparative Pathology·M J HoenerhoffM Kiupel
Aug 12, 2008·Journal of Veterinary Internal Medicine·D R WestworthR J Higgins
Jun 6, 2009·Journal of Veterinary Internal Medicine·K O'NeillS Dow
Apr 27, 2010·Veterinary Pathology·T IdeH Nakayama
Oct 12, 2011·Veterinary Pathology·L B BoozerC L Mariani
Feb 1, 2012·The Cancer Journal·Alissa A ThomasCamilo E Fadul
Mar 1, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Alice NentwigAnna Oevermann
Nov 7, 2014·The Journal of Veterinary Medical Science·Naoki HiroseHiroyuki Nakayama
Jul 7, 2015·Journal of Comparative Pathology·E A SlomaA D Miller
Apr 9, 2016·Oncoimmunology·David C BinderDerek A Wainwright
May 25, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Eun Ju ChoiAndrew D Miller
May 25, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Christian ThomasMartin Hasselblatt
Dec 3, 2016·Journal of Comparative Pathology·A OrtloffO Illanes
Dec 8, 2016·Journal of Comparative Pathology·R McBrideA D Miller
Jun 20, 2017·Advanced Drug Delivery Reviews·Johnathan G LyonRavi V Bellamkonda
May 8, 2018·Journal of Comparative Pathology·D R RissiA D Miller

❮ Previous
Next ❯

Citations

Dec 2, 2020·Journal of the American Animal Hospital Association·Yuya SaitohMasaaki Nishimura
Nov 3, 2020·Frontiers in Veterinary Science·László LehnerGábor Nagy
Jul 2, 2021·Veterinary Pathology·Gregory A KraneChristopher L Mariani

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

The Journal of Veterinary Medical Science
Naoki HiroseHiroyuki Nakayama
Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Eun Ju ChoiAndrew D Miller
© 2021 Meta ULC. All rights reserved